Decreased Levels of Lipoxin A4 and Annexin A1 in Wheezy Infants

Abstract

Objective: Wheezing is a common and challenging health issue in infancy and early childhood. Asthma diagnosis is frequent in patients with a history of recurrent wheezing. A relationship has been reported between asthma and anti-inflammatory mediators such as lipoxin A4 and annexin A1. However, this remains uncertain in wheezy infants. The aim of the present study was to determine lipoxin A4 and annexin A1 levels in wheezy infants. Materials and Methods: Eighty-seven patients aged 6-36 months were included in this study. Demographic characteristics, clinical features, laboratory data, clinical diagnoses, and treatments, if present, were recorded. Patients were divided into 2 groups: patients with wheezing (n = 59) and healthy controls (n = 28). Blood samples were taken and lipoxin A4 and annexin A1 levels were evaluated by ELISA. Results: Lipoxin A4 and annexin A1 levels were significantly lower in the wheezing group than in the control group (p < 0.05). A significant correlation was found between the serum total immunoglobulin E (IgE) level and the percentage and absolute number of eosinophils (p < 0.05). No significant correlation was found in terms of lipoxin A4 and annexin A1 levels, the serum total IgE level, and the percentage and absolute number of eosinophils among groups (p > 0.05). Conclusion: This is the first study to assess lipoxin A4 and annexin A1 levels in wheezy infants. The levels of lipoxin A4 and annexin A1 were found to be low in wheezy infants. We hope that these results will lead to novel therapeutic options for asthma in cases where an optimal treatment modality is lacking.

Study of Serum Level of Lipoxin A4 in Exercise-Induced Bronchoconstriction in Asthmatic Children

“…Our results were consistent with Gungor et al, 2014 [25] who reported decreased levels of LXA4 and ANXA1 in the wheezing children versus the control group. This was important for understanding the pathophysiology of wheezy infants.…”

Airway lipoxin A4/formyl peptide receptor 2–lipoxin receptor levels in pediatric patients with severe asthma

“…18 Adults with severe asthma (SA) have decreased peripheral blood and bronchial LXA 4 concentrations, 16,19,20 and low blood concentrations of LXA 4 have been detected in wheezy infants. 21 However, the bioactivity of LXA 4 has not yet been investigated in asthmatic children.…”

Lipidmediatoren und ihre Rolle bei Entzündungen und Allergien

“…Daher ist es auch nicht verwunderlich, dass eine relativ aktuelle Studie bei giemenden Kindern im Vergleich zu Gesunden eine reduzierte Menge von Lipoxinen, aber auch weniger Annexin A1 nachwies (Eke Gungor et al 2014).…”