Performance of Galactomannan Antigen, Beta-d-Glucan, and Aspergillus-Lateral-Flow Device for the Diagnosis of Invasive Aspergillosis

Metan, Gökhan; Keklik, Muzaffer; Dinç, Gökçen; Pala, Çiğdem; Yıldırım, Afra; Saraymen, Berkay; Köker, Mustafa Yavuz; Kaynar, Leylagül; Eser, Bülent; Çetın, Mustafa

doi:10.1007/s12288-016-0653-3

Cited by 18 publications

(14 citation statements)

References 14 publications

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“…Screening tests were started at the day of an absolute neutrophil count (4,8). Other studies used the EORTC/MSG criteria published in 2008 to define IA (5)(6)(7)9).…”

Section: Resultsmentioning

confidence: 99%

“…GM antigen testing was performed in 2662 serum samples. Mold-active antifungal prophylaxis was administered in two studies (6,7). Fluconazole was the choice of antifungal prophylaxis in other studies (4,5).…”

Section: Resultsmentioning

confidence: 99%

“…In Turkey, access to GM antigen test is available in most of the centers treating high-risk hematology patients, but publication of the experience in the international literature is limited (4)(5)(6)(7)(25)(26)(27). Only one center reported GM antigen as a useful marker for the diagnosis of IA where mold-active prophylaxis was not used (5).…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies reported very low sensitivity (23.07%-35.7%) for GM screening that was performed when posaconazole prophylaxis became the standard of care particularly for patients receiving induction chemotherapy for acute myeloid leukemia (AML) (6,7). However, the specificity was higher than 90%, indicating that a positive GM result should trigger the diagnostic pathway for the early detection of IA (6,7).…”

Section: Discussionmentioning

confidence: 99%

“…In a study from Erciyes University, the serum samples from patients with radiological evidence of IA and from patients without IA (1 to 10 ratio) were re-tested by a modified methodology that was previously proven to increase the sensitivity of GM antigen detection (7,18). The sensitivity increased from 35.7% to 92.3% with a slight decrease in the specificity from 99.6% to 97.6% (7). The method is based on the concentration of GM antigen.…”

Section: Discussionmentioning

confidence: 99%

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Galactomannan antigen detection as a screening tool for early diagnosis of invasive aspergillosis: Experience of Turkish adult patients

Metan¹,

Akan²

2018

Erciyes Med J

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Objective: The aim of the present study was to investigate the usefulness of galactomannan (GM) antigen as a screening test for the early diagnosis of invasive aspergillosis (IA) in adult patients in Turkish centers. Materials and Methods:PubMed was searched using the keywords "galactomannan" and "Turkey." Only studies that used the GM antigen as a screening tool in adult patients were included in the analysis.Results: Four peer-reviewed articles that matched the inclusion criteria were identified. A total of 314 adult patients with several hematological malignancies and who underwent allogeneic hematopoietic stem cell transplantation were included in the four studies. Patients were followed up for 459 neutropenia episodes. GM antigen testing was performed in 2662 serum samples. The sensitivity, specificity, positive predictive value, and negative predictive value were 23.07%-100%, 5.7%-90.36%, 6.7%-73.07%, and 55.5%-100%, respectively. Early diagnosis of IA by GM screening was found in only one patient in one of the four studies. Conclusion:The performance of the GM antigen test as a screening tool in Turkish centers was not promising. However, it can be used as a diagnostic test for patients with clinical and radiological findings suggesting invasive fungal disease.

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“…Screening tests were started at the day of an absolute neutrophil count (4,8). Other studies used the EORTC/MSG criteria published in 2008 to define IA (5)(6)(7)9).…”

Section: Resultsmentioning

confidence: 99%