In the diagnosis of neonatal sepsis importance of gelsolin and relationship with mortality and morbidity

Halis, Hülya; Güneş, Tamer; Korkut, Sabriye; Saraymen, Berkay; Şen, Ahmet; Baştuğ, Osman; Öztürk, Abdullah; Kurtoğlu, Selim

doi:10.1016/j.mehy.2016.06.017

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…A recent study showed that pGSN levels are lower in preterm infants with sepsis than those of control group, and pGSN levels increased after recovery in patient with sepsis. 16 Although pGSN levels decreased in septic patients, in our study there is no statistically significant difference between three clinic scores of patients with bronchiolitis. Thus, we considered that pGSN levels are changed more often in bacterial infections such as sepsis, than viral infections.…”

Section: Discussioncontrasting

confidence: 63%

Gelsolin levels in patients with bronchiolitis

Hüsrevoğlu-Esen¹,

Torun²,

Karakükçü³

et al. 2018

Turk J Pediatr

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Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers can show severity of the disease and help in clinical management. In this study, the aim was to determine the clinical predictiveness of plasma gelsolin levels (pGSN) in acute bronchiolitis. From December 2013 to May 2014, 52 patients with bronchiolitis (aged <24 months) were included in this study. Baseline clinical characteristic, complete blood count, C-Reactive Protein, plasma gelsolin levels, chest X-rays were obtained in all patients. The patients were divided into three groups as mild, moderate and severe based on clinical findings. There was no significant difference in pGSN levels between the control group and 3 study groups according to their clinical scores such as mild, moderate and severe bronchiolitis (p>0.05). Recent studies reported that pGSN levels can be used as a biomarker in sepsis, inflammation and injuries. In this study, we have demonstrated that pGSN level is not a predictive biomarker of bronchiolitis and its severity. Hence, we hypothesized that pGSN levels can be used in bacterial infections rather than viral infections as a biomarker.

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Section: Discussioncontrasting

confidence: 63%

Gelsolin levels in patients with bronchiolitis

Hüsrevoğlu-Esen¹,

Torun²,

Karakükçü³

et al. 2018

Turk J Pediatr

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“…Suhler et al reported a significant reduction in mean gelsolin concentrations when compared with healthy individuals in 51% of patients with sepsis, which correlated with illness severity [ 44 ]. Further studies confirmed that admission plasma gelsolin levels are also lower in neonatal infants and adult patients with severe sepsis than in non-septic critically ill patients in the ICU, including those diagnosed with systemic inflammatory response syndrome (SIRS) [ 17 , 54 , 102 ]. Simultaneous measurement of pGSN depletion with other well-known biomarkers might increase the diagnostic sensitivity and specificity of extracellular gelsolin-based assessments.…”

Section: Alterations In Plasma Gelsolin Concentrations In Differenmentioning

confidence: 99%

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

Piktel

Levental

Durnaś

et al. 2018

IJMS

108

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Gelsolin, an actin-depolymerizing protein expressed both in extracellular fluids and in the cytoplasm of a majority of human cells, has been recently implicated in a variety of both physiological and pathological processes. Its extracellular isoform, called plasma gelsolin (pGSN), is present in blood, cerebrospinal fluid, milk, urine, and other extracellular fluids. This isoform has been recognized as a potential biomarker of inflammatory-associated medical conditions, allowing for the prediction of illness severity, recovery, efficacy of treatment, and clinical outcome. A compelling number of animal studies also demonstrate a broad spectrum of beneficial effects mediated by gelsolin, suggesting therapeutic utility for extracellular recombinant gelsolin. In the review, we summarize the current data related to the potential of pGSN as an inflammatory predictor and therapeutic target, discuss gelsolin-mediated mechanisms of action, and highlight recent progress in the clinical use of pGSN.

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“…Wang et al [16] found similar results in their adult cohort. Similarly, Halis et al, [19] demonstrated the same in their cohort of septic preterm neonates. An ideal biomarker should be easily obtainable, has rapid detection, and reflects normal and pathogenic processes through quantitative and reproducible estimation.…”

Section: Discussionmentioning

confidence: 56%

Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?

Mokhtar,

Sherief,

Kamal

et al. 2024

Medicine

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Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63 ± 20.64 vs 451.83 ± 209.59). It was significantly related to the severity of sepsis and mortality, with significantly lower values among cases with septic shock and multiorgan failure and non-survivors. Follow-up pGSN significantly increased after sepsis improvement in survivors compared to admission values. pGSN might be a reliable diagnostic and prognostic marker for LOS.

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In the diagnosis of neonatal sepsis importance of gelsolin and relationship with mortality and morbidity

Cited by 8 publications

References 22 publications

Gelsolin levels in patients with bronchiolitis

Gelsolin levels in patients with bronchiolitis

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?

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