Autism spectrum disorder (ASD) is a neurodevelopmental difference with increasing global prevalence. Yet, the etiology of ASD is still not unraveled. Individuals with ASD experience difficulties with social skills and communication, and exhibit repetitive and restrictive interests and behaviors. Method: There is yet no comprehensive model of autism that can explain all aspects of autism. Similarly, there exists no known treatment for it. Induced pluripotent stem cell (iPSC), which has been widely used in the regenerative treatment of many diseases in recent years, is promising for a better understanding of the causes of autism. Results: Autism modelling with iPSCs provides several opportunities for understanding the mechanisms underlying autism and developing personalized treatments. Conclusions: This review examines the use of iPSCs in ASD to date, their advantages, and the findings obtained via iPSC modeling of autism.