The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients

Koçyiğit, İsmail; Saraymen, Berkay; Tunçay, Aydın; Mavili, Ertuğrul; Ünal, Aydın; Avcilar, Huseyin; Koker, Mustafa Yavuz; Oymak, Oktay

doi:10.1007/s11255-016-1282-3

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…19 Eventually, in late AVF stenosis, venous neointimal hyperplasia is organized by crucial alphasmooth muscle actin-positive cells together with the expression of several cytokines such as transforming growth factor β, platelet-derived growth factor, endothelial progenitor cells, endothelin, and endothelial progenitor cells. 14,20 The etiological factors of venous neointimal hyperplasia in late AV fistula stenosis have been well described and are commonly divided into two groups: existing factors before AVF creation and subsequent factors after the operation. Existing factors are responsible for endothelial injury, mainly uremia, which leads to a cascade of mediators that regulate oxidative stress, endothelial dysfunction, and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…These processes may result in an impaired vascular response, with migration and proliferation of vascular cells that contribute to venous thickening, resulting in neointimal hyperplasia and fistula stenosis 19 . Eventually, in late AVF stenosis, venous neointimal hyperplasia is organized by crucial alpha‐smooth muscle actin‐positive cells together with the expression of several cytokines such as transforming growth factor β, platelet‐derived growth factor, endothelial progenitor cells, endothelin, and endothelial progenitor cells 14,20 . The etiological factors of venous neointimal hyperplasia in late AV fistula stenosis have been well described and are commonly divided into two groups: existing factors before AVF creation and subsequent factors after the operation.…”

Section: Discussionmentioning

confidence: 99%

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Soluble vascular endothelial growth factor receptor‐1 as a novel marker of arteriovenous fistula stenosis in hemodialysis patients

Koçyiğit

Kahriman

Karakükçü

et al. 2020

Hemodialysis International

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Introduction: Arteriovenous fistula (AVF) stenosis is one of the most important clinical problems in hemodialysis patients. The histopathological findings of neointimal hyperplasia and impaired angiogenesis have been well established in stenotic AVFs. Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) has been implicated in pathological angiogenesis. Thus, we aimed to investigate the association between sVEGFR-1 and AVF stenosis in hemodialysis patients.Methods: This prospective cohort study included 70 patients with end-stage renal disease. Forty-five patients were included in the final analysis, and the median follow-up period was 36 months. Venous stenosis was detected by physical examination and documented by fistulography. Blood samples were analyzed a day before the fistula operation, and serum levels of sVEGFR-1 were measured.Findings: The median sVEGFR-1 level was higher in the stenosis group than in the nonstenosis group (17 pg/mL [89.5%] vs. 5 pg/mL [19.2%], respectively; P < 0.001]. According to body mass index (BMI) categories, obese patients (BMI > 30 kg/m 2 ) had the shortest stenosis-free survival (20 months [9.35-30.65]). Multivariate Cox analysis showed that sVEGFR-1, serum creatinine, and parathyroid hormone levels were associated with AVF stenosis risk. Kaplan-Meier survival curves showed that patients with less than the median value of sVEGFR-1 (<6093.07 pg/mL) had longer cumulative stenosis-free survival than patients with sVEGFR-1 levels above the median value (P < 0.001).Discussion: Increased levels of sVEGFR-1 and obesity were found to be associated with AVF stenosis in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Soluble vascular endothelial growth factor receptor‐1 as a novel marker of arteriovenous fistula stenosis in hemodialysis patients

Koçyiğit

Kahriman

Karakükçü

et al. 2020

Hemodialysis International

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“…In the literature, many studies have shown the favorable effects of EPCs on the vascular healing process. In a study about the effects of EPCs on fistula maturation, Eroğlu et al [26] showed that high CD309 levels had a favorable effect. Moreover, in another study by Gill et al, [22] it was suggested that CD309 and CD133 values were increased temporarily in the peripheral circulation at early phase in patients who underwent coronary artery bypass and in those with burn injury, thus improving revascularization in damaged tissues.…”

Section: Discussionmentioning

confidence: 99%

Is there an association of hematopoietic stem cell and endothelial progenitor cell markers with maturation in forearm arterial repair?

Karaman

Günay

Doğan

et al. 2019

Eklem Hastalik Cerrahisi

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ÖZAmaç: Bu çalışmada, periferik kan ve monositlerdeki hematopoetik kök hücre ve endotelyal progenitör hücre farklılaşma yığılım molekülleri (CD) 34, CD133 ve CD309 ekspresyon düzeylerinin önkolun arteriyel onarımı yapılan hastalarda onarım sahasındaki olgunlaşma üzerindeki etkileri değerlendirildi. Hastalar ve yöntemler: Bu prospektif çalışmaya elbileğinde saplanıcı bir yaralanmaya bağlı iyi tanımlanmış kesiği olup eşlik eden durumu olmayan, Kasım 2014 ve Kasım 2017 tarihleri arasında hastanemizin acil servisine başvuran 30 hasta (23 erkek, 7 kadın; ort. yaş 28.9±1.8 yıl; dağılım, 18-49 yıl) dahil edildi. Önkolda mikrovasküler tekniklerle arteriyel onarım yapılan hastaların vasküler açıklığı Doppler sonografi ile değerlendirildi. Açıklık ve CD34, CD133 ve CD309 gibi hematopoetik kök ve endotelyal progenitör hücre belirteçleri arasındaki ilişkiler akış sitometrisi ile değerlendirildi. Bulgular: Hastalar tamir edilen arterlerde yeterli akım olup olmamasına göre iki gruba ayrıldı. Ortalama CD34 ekspresyon düzeyi olgunlaşma olan grupta 72.09±3.00 iken olgunlaşma olmayan grupta 54.64±7.34 idi ve bu, istatistiksel olarak anlamlı farklılığa işaret etti (p<0.05). Ek olarak, CD34 düzeyinde bir birim artış yeterli akış olasılığını 1.075 kat artırdı. Rezistif indeks değerleri olgunlaşma olan grupta anlamlı olarak daha düşük idi ve CD34 düzeyi arteriyel onarımın olgunlaşması için prediktif idi. Sonuç: Bu çalışmada, bulgular yüksek CD34 ekspresyon düzeyinin arteriyel onarımdan sonra olgunlaşma üzerinde olumlu etkileri olduğunu gösterdi.Anahtar sözcükler: Arteriyel iyileşme, farklılaşma yığılım molekülleri 34, farklılaşma yığılım molekülleri 133, farklılaşma yığılım molekülleri 309, endotelyal progenitör hücre. ABSTRACTObjectives: This study aims to assess the effects of the hematopoietic stem cells and endothelial progenitor cells in peripheral blood and monocyte cluster of differentiation (CD) 34, CD133 and CD309 expression levels on maturation at the repair site in patients who underwent forearm arterial repair. Patients and methods: This prospective study included 30 patients (23 males, 7 females; mean age 28.9±1.8 years; range, 18 to 49 years) with a well-defined cut at the wrist due to a stabbing injury but no comorbid condition who presented to the emergency department of our hospital between November 2014 and November 2017. Vascular patency was assessed by Doppler sonography in patients who underwent forearm arterial repair via micro-vascular techniques. The relationships between patency and hematopoietic stem and endothelial progenitor cell markers such as CD34, CD133 and CD309 were assessed by flow cytometry. Results: The patients were divided into two groups according to presence of sufficient flow in the arteries repaired. The mean CD34 expression level was 72.09±3.00 in the group with maturation whereas it was 54.64±7.34 in the group without maturation, indicating a statistically significant difference (p<0.05). In addition, the likelihood of sufficient flow was increased by 1.075 per one unit increase in CD34 lev...

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“…Despite recent advances in medical and surgical approaches, 20%‐60% of created AVFs fail to mature for dialysis use 7,8 . Several clinical risk factors for AVF failure have been identified such as being elderly, female gender, obesity, diabetes mellitus, presence of cardiovascular disease and peripheral arterial disease, although their utility for predicting AVF failure through predictive models remains unclear 9,10 . Therefore, it is plausible to find a marker for the prediction of AVF failure.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia‐inducible factors in arteriovenous fistula maturation: A prospective cohort study

Koçyiğit

Karakükçü

Tunçay

et al. 2020

Eur J Clin Investigation

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Background: Neointimal hyperplasia is the main cause of arteriovenous fistula (AVF) failure. Hypoxia-inducible factors (HIFs) factors are associated with neointimal hyperplasia. Thus, we investigated the association between HIF-2 alpha (HIF-2α) and AVF maturation in end-stage kidney disease (ESKD) patients. Methods: This prospective cohort study was conducted in 21 voluntary healthy subjects and 50 patients with ESKD who were eligible for AVF creation. Inclusion criteria were being ESKD patients without a history of AVF surgery and dialysis. Eight patients excluded from the study due to having unavailable veins six patients were excluded due to acute thrombosis after surgery. One patient lost to follow-up. A total of 35 patients were included in final analysis. The blood samples were collected a day before the AVF surgery for biochemical parameters and HIF-2α measurement. HIF-2α levels were measured by the ELISA method. Results: Compared with healthy subjects, ESKD patients had a significantly higher level of HIF-2α. [1.3 (1.0-1.9) vs 2.2 (1.6-3.0)] (P = .002). Patients were divided into two groups after the evaluation of AVF maturation, as the mature group (n = 19) and the failure group (n = 16). Serum HIF-2α level was 1.7 (1.1-1.8) in the mature group; however, it was 3.1 (2.8-3.3 in failure group (P < .001). Multiple logistic regression analyses showed that HIF-2α independently predicted AVF maturation. The ROC curve analysis showed that HIF-2α > 2.65 predicted AVF maturation failure with the 87% sensitivity and 94% specificity [AUC:0.947, 95% CI (0.815-0.994), P < .001]. Conclusions: HIF-2-α levels were higher in ESKD patients than healthy subjects. HIF-2-α could be a marker of AVF maturation failure.

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The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients

Abstract: The presence of DM and increased BMI negatively correlated with AVF maturation. High intensity of CD309 expression on monocytes was observed in patients with successful AVF maturation.

Cited by 9 publications

References 44 publications

Soluble vascular endothelial growth factor receptor‐1 as a novel marker of arteriovenous fistula stenosis in hemodialysis patients

Soluble vascular endothelial growth factor receptor‐1 as a novel marker of arteriovenous fistula stenosis in hemodialysis patients

Is there an association of hematopoietic stem cell and endothelial progenitor cell markers with maturation in forearm arterial repair?

Hypoxia‐inducible factors in arteriovenous fistula maturation: A prospective cohort study

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