Trace metal concentrations in hair and nails from Alzheimer’s disease patients: Relations with clinical severity

Köseoğlu, Emel; Köşeoğlu, Rahmi; Kendirci, Murat; Saraymen, Recep; Saraymen, Berkay

doi:10.1016/j.jtemb.2016.09.002

Cited by 42 publications

(24 citation statements)

References 36 publications

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“…Furthermore, the critical role of copper, iron, and other trace redox-active transition metals was shown recently to be implicated in the pathogenesis of AD [ 14 , 15 ]. While our group previously suggested a strong link between oxidative stress and Alzheimer's disease [ 16 , 17 ], we aimed to assess the possible cause/effect relationship between BM abnormal levels dynamics and the increased oxidative damage occurring in AD pathology.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Balmuș

Strungaru

Ciobîcă

et al. 2017

Oxidative Medicine and Cellular Longevity

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Increased interest regarding the biometal mechanisms of action and the pathways in which they have regulatory roles was lately observed. Particularly, it was shown that biometal homeostasis dysregulation may lead to neurodegeneration including Alzheimer's disease, Parkinson disease, or prion protein disease, since important molecular signaling mechanisms in brain functions implicate both oxidative stress and redox active biometals. Oxidative stress could be a result of a breakdown in metal-ion homeostasis which leads to abnormal metal protein chelation. In our previous work, we reported a strong correlation between Alzheimer's disease and oxidative stress. Consequently, the aim of the present work was to evaluate some of the biometals' levels (magnesium, manganese, and iron), the specific activity of some antioxidant enzymes (superoxide dismutase and glutathione peroxidase), and a common lipid peroxidation marker (malondialdehyde concentration), in mild cognitive impairment (n = 15) and Alzheimer's disease (n = 15) patients, compared to age-matched healthy subjects (n = 15). We found increased lipid peroxidation effects, low antioxidant defense, low magnesium and iron concentrations, and high manganese levels in mild cognitive impairment and Alzheimer's disease patients, in a gradual manner. These data could be relevant for future association studies regarding the prediction of Alzheimer's disease development risk or circling through stages by analyzing both active redox metals, oxidative stress markers, and the correlations in between.

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Section: Introductionmentioning

confidence: 99%

Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Balmuș

Strungaru

Ciobîcă

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Maternal exposure to excessive concentrations of copper, arsenic, lead, and cadmium in hair was shown to significantly increase the risk of CHD in offspring. [11,28] Although hair sample could show long-term exposure to nickel, and may even provide us with information regarding metal exposure of the mother prior to pregnancy, [30,31] we also used fetus placental tissues to analyze the nickel exposure which could be more intuitive displayed fetal nickel exposure levels in this study. As we know, nickel could be capable of crossing the placenta barrier and exerting the toxicity on the embryonic development.…”

Section: Discussionmentioning

confidence: 99%

Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Zhang

Chen

et al. 2019

Medicine

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Background: Previous studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between exposure to nickel and CHDs occurrence in offspring. The aim of this study was to analyze the association between nickel exposure in mothers and the risk of CHDs in offspring. Materials and methods: To explore the association of nickel exposure and occurrence of CHD, a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of nickel in hair of pregnant woman and fetal placental tissue were measured and used a logistic regression analysis to explore the relationship between nickel exposure and risk of CHD. Results: The median concentrations of nickel were 0.629 ng/mg, P < .05 (adjusted odds ratio [aOR], 1.326; 95% CI, 1.003–1.757) and 0.178 ng/mg, P < .05 (aOR, 2.204; 95% CI, 0.783–6.206), in maternal hair and in fetal placental tissue in the CHD group, respectively. Significant differences in the level of nickel in hair were also found in the different CHD subtypes including septal defects ( P < .05), conotruncal defects ( P < .05), right ventricular outflow tract obstruction ( P < .01), and left ventricular outflow tract obstruction ( P < .05). Dramatically different nickel concentrations in fetal placenta tissue were found in cases with other heart defects ( P < .05). Conclusions: The finding suggested that the occurrence of CHDs may be associated with nickel exposure.

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“…Moreover, because metal analysis of brain tissues must be conducted post‐mortem, it cannot be used as a diagnostic tool for living patients. For this reason, attempts to analyze metal concentrations in other tissues, whose sampling would be more convenient, have been performed . However, more‐reliable results than those reported so far must be obtained before a feasible diagnostic method for AD based on metal ions levels can be developed.…”

Section: Beyond the Aβ Peptides: The Contribution Of Mass Spectrometrmentioning

confidence: 99%

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

Grasso

2018

Mass Spectrometry Reviews

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Amyloid-β peptide (Aβ) accumulation and aggregation have been considered for many years the main cause of Alzheimer's disease (AD), and therefore have been the principal target of investigation as well as of the proposed therapeutic approaches (Grasso [2011] Mass Spectrom Rev. 30: 347-365). However, the amyloid cascade hypothesis, which considers Aβ accumulation the only causative agent of the disease, has proven to be incomplete if not wrong. In recent years, actors such as metal ions, oxidative stress, and other cofactors have been proposed as possible co-agents or, in some cases, main causative factors of AD. In this scenario, MS investigation has proven to be fundamental to design possible diagnostic strategies of this elusive disease, as well as to understand the biomolecular mechanisms involved, in the attempt to find a possible therapeutic solution. We review the current applications of MS in the search for possible Aβ biomarkers of AD to help the diagnosis of the disease. Recent examples of the important contributions that MS has given to prove or build theories on the molecular pathways involved with such terrible disease are also reviewed.

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Trace metal concentrations in hair and nails from Alzheimer’s disease patients: Relations with clinical severity

Cited by 42 publications

References 36 publications

Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

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