Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Zhang, Nannan; Chen, Ming; Li, Jun; Deng, Ying; Li, Shengli; Guo, Yi-Xiong; Li, Nana; Lin, Yuan; Yu, Ping; Liu, Zhen; Zhu, Jun

doi:10.1097/md.0000000000015352

Cited by 25 publications

(21 citation statements)

References 42 publications

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“…Ni vehiculated by PM10, in particular, has been linked with decrements in forced expiratory volume in the first second [99] and, according to data from school children living in an e-waste recycling area, the accumulation of Ni in serum could generate oxidative damage and decreased pulmonary function [19]. A recent study determining the concentrations of Ni in hair of pregnant women and in fetal placental tissues demonstrated a possible effect of Ni exposure in increasing the occurrence of congenital heart defects in offspring [100]. Finally, Ni is a IARC Group 1 carcinogen, and a possible relationship has been suggested between urinary Ni levels and childhood acute leukemia, secondary to oxidative DNA damage [101].…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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The impact of waste incinerators is usually examined by measuring environmental pollutants. Biomonitoring has been limited, until now, to few metals and to adults. We explored accumulation of a comprehensive panel of metals in children free-living in an urban area hosting two waste incinerators. Children were divided by georeferentiation in exposed and control groups, and toenail concentrations of 23 metals were thereafter assessed. The percentage of children having toenail metal concentrations above the limit of detection was higher in exposed children than in controls for Al, Ba, Mn, Cu, and V. Exposed children had higher absolute concentrations of Ba, Mn, Cu, and V, as compared with those living in the reference area. The Tobit regression identified living in the exposed area as a significant predictor of Ba, Ni, Cu, Mn, and V concentrations, after adjusting for covariates. The concentrations of Ba, Mn, Ni, and Cu correlated with each other, suggesting a possible common source of emission. Exposure to emissions derived from waste incinerators in an urban setting can lead to body accumulation of specific metals in children. Toenail metal concentration should be considered a noninvasive and adequate biomonitoring tool and an early warning indicator which should integrate the environmental monitoring of pollutants.

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Section: Discussionmentioning

confidence: 99%

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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“…To explore the association of nickel exposure and occurrence of congenital heart defects (CHD), a case–control study with 490 controls and 399 cases was conducted in China (Zhang et al., 2019). The cases included septal defects, conotruncal defects, right and left ventricular outflow tract obstruction, anomalous pulmonary venous return and other heart defects.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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“…ln q e C e = ln(k E q max ) − 1 q max q e (10) where q max is the maximum capacity of adsorption, K E (L•mg -1 ) refers to the Elovich constant and q e is the amount of heavy metals adsorbed at equilibrium. From the slope and intercept of Figure 5e, values of q max and K E can be calculate (Table 1) [68].…”

Section: Adsorption Isothermmentioning

confidence: 99%

Effective Adsorption of Hexavalent Chromium and Divalent Nickel Ions from Water through Polyaniline, Iron Oxide, and Their Composites

2020

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Water pollution caused by industrial wastes containing heavy metals and dyes is a major environmental problem. This study reports on the synthesis, characterization, and utilizations of Polyaniline (PANI) and its composites with Fe3O4 for the removal of hexavalent chromium Cr(VI) and divalent nickel Ni(II) ions from water. The adsorption data were fitted in Freudlich, Langmuir, Tempkin, Dubbanin–Ruddishkawich (D–R), and Elovich adsorption isotherms. The Freundlich isotherm fits more closely to the adsorption data with R2 values of 0.9472, 0.9890, and 0.9684 for adsorption of Cr(VI) on Fe3O4, PANI, and PANI/Fe3O4 composites, respectively, while for adsorption of Ni(II) these values were 0.9366, 0.9232, and 0.9307 respectively. The effects of solution pH, initial concentration, contact time, ionic strength, and adsorbent dosage on adsorption behavior were investigated. The adsorption ability of composites was compared with pristine PANI and Fe3O4 particles. Activation energy and other thermodynamic properties such as changes in enthalpy, entropy, and Gibbs free energy indicated spontaneous and exothermic adsorption.

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Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring

Cited by 25 publications

References 42 publications

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Update of the risk assessment of nickel in food and drinking water

Effective Adsorption of Hexavalent Chromium and Divalent Nickel Ions from Water through Polyaniline, Iron Oxide, and Their Composites

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