Graphene Oxide (GO) has attracted tremendous attention as a most promising nanomaterial among the carbon family since itsemerged as a polynomial functional tool bearing rational application in diverse fields such...

Polymer grafted magnetic graphene oxide (GO–PVP–Fe3O4) as an efficient nanocarrier for the delivery of anticancer drug quercetin.

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: Natural products have widely been used in applications ranging from antibacterial, antiviral, antifungal and various other medicinal applications. Use of these natural products was recognized way before the establishment of basic chemistry behind the disease and the chemistry of plant metabolites. After the establishment of plant chemistry various new horizons evolved, and application of the natural products breached the orthodox limitations. In one such interdisciplinary area, use of plant materials in the synthesis of nano particles (NPs) has exponentially emerged. This advancement has offered various environment friendly methods where hazardous chemicals are completely replaced by natural products in the sophisticated and hectic synthesis processes. This review is an attempt to understand the mechanism of metal nano particles synthesis using plant materials. It includes details on the role of plant’s secondary metabolites in the synthesis of nano particles including the mechanism of action. In addition, use of these nano materials has widely been discussed along with the possible mechanism behind their antimicrobial and catalytic action.

Background: In particular, combinatorial use of anticancer drugs, dual or multiple, onto a specific nanocarrier is one of the most hopeful attempts in the field of drug delivery. The current work reports potassium contained graphene oxide (K-GO) as a nanocarrier in the drug delivery system of two anticancer drugs, gefitinib (GEF) and camptothecin (CPT), simultaneously. Methods: To characterize K-GO, K-GO-related single and combined drug systems, different techniques has been performed and studied using spectroscopic tools (Thermo gravimetric Analysis (TGA 4000), UV–visible spectroscopy, Raman spectroscopy, Transmission electron microscopy (TEM)). The in vitro cytotoxicity tests of K-GO, single drug system and the combined drug system were also performed in the human breast cancer MDA-MB-231 cells. Results: The release profile of the dual drug conjugates grafted on to the surface of K-GO was found up to 38% in PBS solution over 72hr. The percentage of MDA-MB-231 cell viability were about 18% when treated with K-GO-GEF-CPT combined system, for K-GO, K-GO-GEF, and K-GO-CPT that were only 79 %, 31% and 32 % respectively. Conclusion: We studied the loading, release, and delivery of two anticancer drugs onto the fluorescent nanocarrier i.e. K-GO. Due to superb aqueous solubility, excellent biocompatibility and richness of potassium in it make them a promising nanocarrier for single or multiple drug delivery. With this, our novel findings revealed that the loading capacity and cytotoxicity of combined drug loaded system superior then that of individual drug system towards human breast cancer cells.

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