Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells

Matiyani, Monika; Rana, Anita; Pal, Mintu; Rana, Sravendra; Melkani, Anand B.; Sahoo, Nanda Gopal

doi:10.1039/d1ra05382e

Cited by 23 publications

(11 citation statements)

References 44 publications

(54 reference statements)

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“…These results confirmed that GO-based materials exhibited a good sustainable release profile, because of which they can be used as a drug delivery system. This can be adequate to achieve a desirable local concentration release of the drugs during the initial few hours [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Graphene Oxide/Quercetin and Graphene Oxide/Juglone Nanostructured Platforms as Effective Drug Delivery Systems with Biomedical Applications

et al. 2022

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In this paper, novel drug delivery systems (DDS) were designed based on graphene oxide (GO) as nanocarrier, loaded with two natural substances (quercetin (Qu) and juglone (Ju)) at different concentrations. The chemical structure and morphology of the synthesized GO-based materials were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and Raman spectroscopy. The antibacterial activity was evaluated against standard strains, Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, and Candida albicans ATCC 10231. Results demonstrated excellent antimicrobial activity, with a 5 log reduction of E. coli and a 1 log to 3.04 log reduction of S. aureus populations. Reduction rates were above 90%. Biocompatibility tests were also performed on GO-based materials, and the results showed biocompatible behavior for both L929 fibroblast cell line and BT474 breast cancer cells at lower concentrations. The identity of Qu and Ju was demonstrated by matrix-assisted laser desorption/ionization (MALDI) analysis, showing the compounds’ mass with high accuracy. In addition, specific properties of GO made it a versatile matrix for the MALDI analysis. The results of this study indicated that GO-based platforms may be suitable for applications in many areas for the effective and beneficial use of hydrophobic compounds such as Ju and Qu.

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Section: Resultsmentioning

confidence: 99%

Novel Graphene Oxide/Quercetin and Graphene Oxide/Juglone Nanostructured Platforms as Effective Drug Delivery Systems with Biomedical Applications

et al. 2022

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“…229,230 In 2022, polymer-grafted magnetic GO (GO-PVP-Fe 3 O 4 ) was successfully developed and employed in anticancer drug delivery. 231 GO was first functionalized with polyvinylpyrrolidone (PVP) before being implanted with magnetic nanoparticles (Fe 3 O 4 ) using a simple and efficient chemical process. Noncovalent interactions were used to load an anticancer drug quercetin (QSR) on GO-PVP-Fe 3 O 4 , as shown in Figure 31.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“… Schematic representation of the synthesis of magnetic GO and drug loading on magnetic GO. Reproduced with permission from ref ( 248 ). Copyright @2022, Royal Society of Chemistry, Royal Society of Chemistry Advances.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

An Update on Graphene Oxide: Applications and Toxicity

et al. 2022

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Graphene oxide (GO) has attracted much attention in the past few years because of its interesting and promising electrical, thermal, mechanical, and structural properties. These properties can be altered, as GO can be readily functionalized. Brodie synthesized the GO in 1859 by reacting graphite with KClO 3 in the presence of fuming HNO 3 ; the reaction took 3−4 days to complete at 333 K. Since then, various schemes have been developed to reduce the reaction time, increase the yield, and minimize the release of toxic byproducts (NO 2 and N 2 O 4 ). The modified Hummers method has been widely accepted to produce GO in bulk. Due to its versatile characteristics, GO has a wide range of applications in different fields like tissue engineering, photocatalysis, catalysis, and biomedical applications. Its porous structure is considered appropriate for tissue and organ regeneration. Various branches of tissue engineering are being extensively explored, such as bone, neural, dentistry, cartilage, and skin tissue engineering. The band gap of GO can be easily tuned, and therefore it has a wide range of photocatalytic applications as well: the degradation of organic contaminants, hydrogen generation, and CO 2 reduction, etc. GO could be a potential nanocarrier in drug delivery systems, gene delivery, biological sensing, and antibacterial nanocomposites due to its large surface area and high density, as it is highly functionalized with oxygen-containing functional groups. GO or its composites are found to be toxic to various biological species and as also discussed in this review. It has been observed that superoxide dismutase (SOD) and reactive oxygen species (ROS) levels gradually increase over a period after GO is introduced in the biological systems. Hence, GO at specific concentrations is toxic for various species like earthworms, Chironomus riparius, Zebrafish, etc.

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“…Nanocomposites fabricated by functionalization of GO with polyvinylpyrrolidone (PVP) and then grafted with Fe 3 O 4 NPs loaded with quercetin exhibited pH-responsive controlled drug release and biocompatibility to non-tumorigenic epithelial HEK 293T cells, with higher toxicity to MDA MB 231 human breast cancer cells than free quercetin. Moreover, targeted drug delivery using this magnetic GO nanocomposite can be controlled by an external magnetic field [ 147 ]. Fe 3 O 4 −GO nanohybrids coated with β-cyclodextrin−cholic acid−hyaluronic acid polymer, characterized with multiple-targeted features (the cholic acid supplied the hepatic target, CD44-receptor target of hyaluronic acid, and magnetic target of Fe 3 O 4 ), exhibited local chemo-photothermal synergistic effects via directly generated apoptosis of hepatocellular carcinoma cells, trigging the release of encapsulated camptothecin, resulting in a tumor inhibition rate >90%; this nanohybrid could be used for enhanced liver tumor therapy [ 148 ].…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells

Abstract: Polymer grafted magnetic graphene oxide (GO–PVP–Fe3O4) as an efficient nanocarrier for the delivery of anticancer drug quercetin.

Cited by 23 publications

References 44 publications

Novel Graphene Oxide/Quercetin and Graphene Oxide/Juglone Nanostructured Platforms as Effective Drug Delivery Systems with Biomedical Applications

Novel Graphene Oxide/Quercetin and Graphene Oxide/Juglone Nanostructured Platforms as Effective Drug Delivery Systems with Biomedical Applications

An Update on Graphene Oxide: Applications and Toxicity

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

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