Nephroprotective effect of extract Etlingera elatior (Jack) R.M. Smith on CCl4-induced nephrotoxicity in rats

Fristiohady, Adryan; Wahyuni, Wahyuni; Ilyas, Muhammad; Bafadal, Mentarry; Purnama, La Ode Muhammad Julian; Sangadji, Firasmi; Malaka, Muhammad Hajrul; Malik, Fadhliyah; Hong, Junli; Yodha, Agung Wibawa Mahatva; Sahidin, Idin

doi:10.5614/crbb.2019.1.2/dapm6106

Cited by 7 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Therefore, the E. elatior fruit will be inspected for the anti-inflammatory potential including its beneficial role in reducing CKD progressivity. [9][10][11]…”

Section: Introductionmentioning

confidence: 99%

Modulation effects of Etlingera elatior ethanol extract as anti-inflammatory on chronic kidney disease in mice with hypertension and diabetes

Widyarini

Indarto

Soetrisno

et al. 2022

JPTCP

View full text Add to dashboard Cite

The incidence of diabetes increased significantly around the world in accordance with lifestyle and change in eating behaviour. Streptozotocin-Nicotinamide (STZ-NA) is capable of inducing Diabetes Mellitus type 2 in experimental animals for insulin resistance. In this research, we inspect the therapeutic potential of Etlingera elatior ethanol extract (EEEE) on diabetes associated with diabetic nephropathy and hypertension complications in mice models. Diabetes and hypertension are induced in mice using STZ 45 mg/kgBB and NA 110 mg/kgBB, followed by unilateral ureter ligation (UUO) for 4 weeks after a week of STZ-NA induction. The EEEE solution was given in the last 4 weeks with doses of 200, 400, 600, and 800 mg/kgBB. The results of this study prove the effect of vanillic acid on improving systolic blood pressure, plasma creatinine, plasma glucose, albuminuria and reducing the inflammatory marker high sensitivity C-reactive protein (hs-CRP). Histopathology of kidney is under investigation for being part of diabetes hypertension pathology. Treatment using EEEE 600 and 800 mg/kgBB for 4 weeks in experimental mice results in the decrease of plasma glucose, systolic blood pressure, plasma creatinine, albuminuria, and hs-CRP, including the restoration of kidney histology significantly compared to 200 and 400 mg/kgBB doses. This result concludes that EEEE offers modulation effects on

show abstract

“…9 Therefore, the E. elatior fruit will be inspected for the anti-inflammatory potential including its beneficial role in reducing CKD progressivity. [9][10][11]…”

Section: Introductionmentioning

confidence: 99%

Modulation effects of Etlingera elatior ethanol extract as anti-inflammatory on chronic kidney disease in mice with hypertension and diabetes

Widyarini

Indarto

Soetrisno

et al. 2022

JPTCP

View full text Add to dashboard Cite

show abstract

“…Further, the ethanol extract of E. elatior fruit with a dose of 100, 300, 1000 mg / kg in mus musculus has pharmacological activities as an anti-allergic [ 1 5 ] . Nephroprotective effect of E. elatior fruit extract at doses of 200, 300, 400 mg/Kg BW of mus musculus [16]. The acetone extract of E. elatior leaf at a dose of 250 g/mL has antiproliferative and apoptotic activity [17].…”

Section: Introductionmentioning

confidence: 99%

Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Nurhayatun

Chitra²

2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Sepsis is the consequence of widespread inflammation in the body. Inflammation and blood clotting during sepsis cause reduced blood flow to vital organs which can lead to organ failure and even death. Kecombrang (Etlingera elatior) is proposed to have the ability to suppress inflammation and oxidative stress through the control of NF-kB. This study aims to investigate the effect of the extract of Kecombrang fruit on the level of NF-kB in Mus musculus sepsis model. This laboratory experimental study was conducted on a total of 20 Mus musculus which were equally divided into four groups. Group received lipopolysaccharide (LPS) induction as the control group. MP1 group received LPS induction and pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days before induction of LPS. MP2 Group received LPS induction and treated with methanol extract of Kecombrang fruit (4.2 mg/20 gr) for 5 days after induction of LPS. MP3 group received LPS induction and treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) at the same time of LPS induction. The measured outcome was the serum level of NF-kB. Data were analyzed using ANOVA with p <0.05. Pretreated extracts of Kecombrang fruit significantly decrease the serum levels of NF-kB (p<0.05). The beneficial effects of extracts of Kecombrang fruit in sepsis are evident from the observations. It means that the extract of Kecombrang can be exploited in the treatment of sepsis.

show abstract

“…Sepsis occurs as an exaggerated inflammatory response to proinflammatory cytokines against infection [11]. Activation of nuclear factor B (NF-B) mediates the transcriptional expression of most pro-inflammatory genes that play an important role in the pathophysiology and pathogenesis of sepsis [12]. One of the pro-inflammatory cytokines activated by NF-B is interleukin-1β (IL-1β).…”

Section: Introductionmentioning

confidence: 99%

“…The cellular activation complex (neutrophils, monocytes, and microvascular endothelial cells), the neuroendocrine system, complement activation, coagulation activation, and the fibrinolytic system play a role in the sepsis state leading to a cytokine storm [12], [13]. This condition is characterized by an inflammatory reaction by pro-inflammatory cytokines, endothelial damage caused by lipid peroxidation, mitochondrial damage, and DNA [17].…”

Section: Introductionmentioning

confidence: 99%

Empirical Study of Anti-Inflammatory Effects of Kecombrang (Etlingera elatior) in Mus musculus Sepsis Model

Nurhayatun

Purwanto

Soetrisno

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Mice used as experimental animals in the laboratory belong to the genus Mus, subfamily Murinae, family Muridae, superfamily Muroidea, order Rodentia, and class M. musculus , these mice are also referred to as home mice. Mice have been used as standard animals in toxicology, teratology, and carcinogenesis tests, even today, mice have also been used for behavioral, neurologic, nutritional, genetic, immunological, infectious, metabolic, and degenerative disease studies. Animal models of sepsis with intraperitoneal or intravenous injection of lipopolysaccharide (LPS) have been widely used for sepsis research. LPS induces systemic inflammation that mimics the early phase of sepsis. LPS injection causes kidney injury, including a decrease in glomerular filtration rate, an increase in blood urea nitrogen, and an increase in neutrophil infiltration in the kidney. The injectable dose of LPS can be titrated to mimic early sepsis without hemodynamic compromise, which has been useful for studying the systemic and renal responses. The response during the early phase of sepsis is that doses of LPS are usually used to induce systemic hypotension and decrease glomerular perfusion, whereas low doses of LPS do not cause systemic hypotension but still decrease glomerular perfusion. There are several advantages of LPS compared to others, namely, the method used is simple and the model is very controlled and standardized. The dose of endotoxin that causes 50% mortality in mice is 1–25 mg/kg. In this study, mice were given intraperitoneal injection of LPS at a dose of 0.3 mg/kg BW. LPS injection was given to the positive control group and treatment group 1, treatment group 2, and treatment group 3 at the start of the study.

show abstract

Nephroprotective effect of extract Etlingera elatior (Jack) R.M. Smith on CCl4-induced nephrotoxicity in rats

Cited by 7 publications

References 11 publications

Modulation effects of Etlingera elatior ethanol extract as anti-inflammatory on chronic kidney disease in mice with hypertension and diabetes

Modulation effects of Etlingera elatior ethanol extract as anti-inflammatory on chronic kidney disease in mice with hypertension and diabetes

Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Empirical Study of Anti-Inflammatory Effects of Kecombrang (Etlingera elatior) in Mus musculus Sepsis Model

Contact Info

Product

Resources

About