The incidence of diabetes increased significantly around the world in accordance with lifestyle and change in eating behaviour. Streptozotocin-Nicotinamide (STZ-NA) is capable of inducing Diabetes Mellitus type 2 in experimental animals for insulin resistance. In this research, we inspect the therapeutic potential of Etlingera elatior ethanol extract (EEEE) on diabetes associated with diabetic nephropathy and hypertension complications in mice models. Diabetes and hypertension are induced in mice using STZ 45 mg/kgBB and NA 110 mg/kgBB, followed by unilateral ureter ligation (UUO) for 4 weeks after a week of STZ-NA induction. The EEEE solution was given in the last 4 weeks with doses of 200, 400, 600, and 800 mg/kgBB. The results of this study prove the effect of vanillic acid on improving systolic blood pressure, plasma creatinine, plasma glucose, albuminuria and reducing the inflammatory marker high sensitivity C-reactive protein (hs-CRP). Histopathology of kidney is under investigation for being part of diabetes hypertension pathology. Treatment using EEEE 600 and 800 mg/kgBB for 4 weeks in experimental mice results in the decrease of plasma glucose, systolic blood pressure, plasma creatinine, albuminuria, and hs-CRP, including the restoration of kidney histology significantly compared to 200 and 400 mg/kgBB doses. This result concludes that EEEE offers modulation effects on
Culex quinquefasciatus L. is a vector mosquito for bancroftian filariasis in an urban area. One way to prevent the mosquito bites is the use of repellents. The study aims to reveal the potency of Acorus calamus rhizome oil as a repellent against Cx. quinquefasciatus. Experimental 90 mosquitoes were divided into three groups and two groups were treated with different repellents. One group was treated with sari puspa and another group with Calamus rhizome oil. The fluid group was the control group. Each group was treated four times. ANOVA test gave F test > F table, and t test (α = 5%) showed that t test > t table. This statistic test supported a conclusion that Calamus rhizome oil (Acorus calamus L.) was a potential repellent against Cx. quinquefasciatus.
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