Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Abstract

Sepsis is the consequence of widespread inflammation in the body. Inflammation and blood clotting during sepsis cause reduced blood flow to vital organs which can lead to organ failure and even death. Kecombrang (Etlingera elatior) is proposed to have the ability to suppress inflammation and oxidative stress through the control of NF-kB. This study aims to investigate the effect of the extract of Kecombrang fruit on the level of NF-kB in Mus musculus sepsis model. This laboratory experimental study was conducted on a total of 20 Mus musculus which were equally divided into four groups. Group received lipopolysaccharide (LPS) induction as the control group. MP1 group received LPS induction and pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days before induction of LPS. MP2 Group received LPS induction and treated with methanol extract of Kecombrang fruit (4.2 mg/20 gr) for 5 days after induction of LPS. MP3 group received LPS induction and treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) at the same time of LPS induction. The measured outcome was the serum level of NF-kB. Data were analyzed using ANOVA with p <0.05. Pretreated extracts of Kecombrang fruit significantly decrease the serum levels of NF-kB (p<0.05). The beneficial effects of extracts of Kecombrang fruit in sepsis are evident from the observations. It means that the extract of Kecombrang can be exploited in the treatment of sepsis.