2017
DOI: 10.18632/aging.101167
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Abstract: Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG per… Show more

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Cited by 76 publications
(60 citation statements)
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“…Physical exercise has also been shown to affect autophagy. Resistance exercise enhances autophagy flux in peripheral blood mononuclear cells of aged subjects [37], and acute exercise increases some autophagy markers in the cerebral cortex of mice [38]. However, a direct correlation between physical exercise-stimulated autophagy flux in the brain and the prevention of age-associated cognitive deficits is still missing.…”
Section: Autophagy In the Central Nervous System (Cns)mentioning
confidence: 99%
“…Physical exercise has also been shown to affect autophagy. Resistance exercise enhances autophagy flux in peripheral blood mononuclear cells of aged subjects [37], and acute exercise increases some autophagy markers in the cerebral cortex of mice [38]. However, a direct correlation between physical exercise-stimulated autophagy flux in the brain and the prevention of age-associated cognitive deficits is still missing.…”
Section: Autophagy In the Central Nervous System (Cns)mentioning
confidence: 99%
“…Previous studies have reported ER stress can be trigger by obesity or metabolic factors such as lipids, glucose and cytokines [32][33][34] . was common in high-fat feeding, genetic obesity and elderly [34,35] . These results demonstrated that autophagic imbalance and ER dysfunction were the main pathway that response to the pathological factor, including lipotoxicity, inflammation and insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
“…The resistance training for the elderly can reduce muscle decay, increase muscle strength, and improve mobility. 12 In this study, the self-developed muscle strength ladder training was used to perform resistance exercises, which helps patients to change their postures autonomously. The patient sat on a nursing bed and pulled the flexible ladder section to reciprocate the upper body to exercise the upper limbs and abdominal muscles.…”
Section: Discussionmentioning
confidence: 99%