2017
DOI: 10.3390/ijms18030598
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Abstract:Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of toxic molecules and organelles to the lysosome by autophagy is crucial for neuronal health and survival. However, we propose that the (dys)regulation of autophagy in microglia also affects innate immune functions such as phagocytosis and inflammation, which in turn contribute to the pathophysiology of aging and neurodegenerati… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

3
184
0
1

Year Published

2017
2017
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 249 publications
(188 citation statements)
references
References 167 publications
3
184
0
1
Order By: Relevance
“…Inhibition of mTORC1 kinase activity triggers the activation of transcription factor EB (TFEB) that promotes transcription of autophagy and lysosome related genes, including Atg5, Atg12 and Atg16 [48]. Through several phosphorylation events, mTORC1 can unleash the kinase activity of the ULK1 complex, which in turns activates its downstream complex Vps34.…”
Section: Major Cancer-related Signaling Pathways With Links To Admentioning
confidence: 99%
“…Inhibition of mTORC1 kinase activity triggers the activation of transcription factor EB (TFEB) that promotes transcription of autophagy and lysosome related genes, including Atg5, Atg12 and Atg16 [48]. Through several phosphorylation events, mTORC1 can unleash the kinase activity of the ULK1 complex, which in turns activates its downstream complex Vps34.…”
Section: Major Cancer-related Signaling Pathways With Links To Admentioning
confidence: 99%
“…The autophagy is crucial for neuronal health and survival, the delivery of toxic molecules and organelles from neuronal apoptotic cells to microglia lysosomes may be acutely and/or chronically dysregulated by senescence, affecting phagocytosis and inflammation-innate immune functions in all age-associated neurodegenerative diseases [83]. There are two phenotypes of activated microglia: M1 (the cells become more cytotoxic by releasing additional pro-inflammatory cytokines-TNF, Il-1β, Il-6, and free radicals [84]), and M2, which becomes more anti-inflammatory, by secreting anti-inflammatory cytokines and neurotrophic factors and helps repair local damage [82].…”
Section: Sex Hormones In Neurodegenerative Processes and Diseases 132mentioning
confidence: 99%
“…In patients affected by MS, several autophagy-related genes (e.g., ATG-16L2, ATG-9A, and ULK-1) are overexpressed [1] , therefore the hypothesis is that over-activation of autophagy may contribute to autoreactive T lymphocyte survival [18] . Given the pivotal roles of the autophagy in these neurodegenerative diseases, the targeting of some key pathways of the inflammatory process provides new insights into the diagnosis and the modulation of this process represents a new therapeutic strategy for neuroprotection [1] .…”
mentioning
confidence: 99%
“…Autophagy is a fundamental regulatory cellular mechanism, which enables cells to survive after a checked clearance of damaged organelles and proteins and a recycle of necessary molecules like amino acids and fatty acids to maintain homeostasis [1] . There are a lot of factors able to influence autophagy in the states of health and disease.…”
mentioning
confidence: 99%
See 1 more Smart Citation