We present an integrated functional contact lens, composed of a differential glucose sensor module, metal interconnects, sensor read-out circuit, antenna and telecommunication circuit, to monitor tear glucose levels wirelessly, continuously and non-invasively. The electrochemical differential sensor module is based on immobilization of activated and de-activated glucose oxidase. We characterized the sensor on a model polymer eye and determined that it showed good repeatability, molecular interference rejection and linearity in the range of 0–2 mM glucose, covering normal tear glucose concentrations (0.1–0.6 mM). We also report the temperature, ageing and protein-fouling sensitivity of the sensor. We report the design and implementation of a low-power (3 µW) sensor read-out and telecommunication circuit to deliver wireless power and transmit data for the sensor module. Using this small chip (0.36 mm2), we produced an integrated contact lens with sensors and demonstrated wireless operation of the system and glucose read-out over the distance of several centimeters.
We present the design, construction, and in vivo rabbit testing of a wirelessly powered contact lens display. The display consists of an antenna, a 500 x 500 µm 2 silicon power harvesting and radio integrated circuit, metal interconnects, insulation layers, and a 750 x 750 µm 2 transparent sapphire chip containing a micro-light emitting diode with peak emission at 475 nm, all integrated onto a contact lens. The display can be powered wirelessly from 1 m in free space and ~2 cm in vivo on a rabbit. The display was tested on live, anesthetized rabbits with no observed adverse effect. In order to extend display capabilities, design and fabrication of micro-Fresnel lenses on a contact lens are presented to pave the way toward a multi-pixel display that can be worn in the form of a contact lens. Contact lenses with integrated micro-Fresnel lenses were also tested on live rabbits and showed no adverse effect.
We present progress toward a wirelessly-powered active contact lens comprised of a transparent polymer substrate, loop antenna, power harvesting IC, and micro-LED. The fully integrated radio power harvesting and power management system was fabricated in a 0.13 μm CMOS process with a total die area of 0.2 mm(2). It utilizes a small on-chip capacitor for energy storage to light up a micro-LED pixel. We have demonstrated wireless power transfer at 10 cm distance using the custom IC and on-lens antenna.
A branch-like Mo-doped Ni3S2 nanoforest is presented as a robust electrocatalyst for boosted energy-saving H2 production through the overall urea electrolysis.
By utilizing a differential tunable active inductor for the LC-tank, a wide tuning-range CMOS voltage-controlled oscillator (VCO) is presented. In the proposed circuit topology, the coarse frequency tuning is achieved by the tunable active inductor, while the fine tuning is controlled by the varactor. Using a 0.18-m CMOS process, a prototype VCO is implemented for demonstration. The fabricated circuit provides an output frequency from 500 MHz to 3.0 GHz, resulting in a tuning range of 143% at radio frequencies. The measured phase noise is from 101 to 118 dBc/Hz at a 1-MHz offset within the entire frequency range. Due to the absence of the spiral inductors, the fully integrated VCO occupies an active area of 150 300 m 2 .
With the aim of a reliable biosensing exhibiting enhanced sensitivity and selectivity, this study demonstrates a dopamine (DA) sensor composed of conductive poly(3,4‐ethylenedioxythiophene) nanotubes (PEDOT NTs) conformally coated with porphyrin‐based metal–organic framework nanocrystals (MOF‐525). The MOF‐525 serves as an electrocatalytic surface, while the PEDOT NTs act as a charge collector to rapidly transport the electron from MOF nanocrystals. Bundles of these particles form a conductive interpenetrating network film that together: (i) improves charge transport pathways between the MOF‐525 regions and (ii) increases the electrochemical active sites of the film. The electrocatalytic response is measured by cyclic voltammetry and differential pulse voltammetry techniques, where the linear concentration range of DA detection is estimated to be 2 × 10−6–270 × 10−6
m and the detection limit is estimated to be 0.04 × 10−6
m with high selectivity toward DA. Additionally, a real‐time determination of DA released from living rat pheochromocytoma cells is realized. The combination of MOF5‐25 and PEDOT NTs creates a new generation of porous electrodes for highly efficient electrochemical biosensing.
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