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We describe a rare case of healing from low differentiated cholangiocarcinoma stage T4N1M0 with atypical genetic mutation in gene BRAF V600E for this tumor. A 38-year-old female patient was operated in National Surgery Institute due to cholangiocellular carcinoma (CCA) of left liver lobe with anterior abdominal wall invasion, invasion into diaphragm, pericardium. Left liver resection with lymphatic dissection, pericardial resection was performed. Adjuvant chemotherapy (GEMOX) didn't give any results.Treatment with pembrolizumab also didn't result in any improvement. Next generation sequencing molecular tumor profiling revealed mutation in BRAF V600E gene. Target therapy with dabrafenib and trametinib, a BRAF gene inhibitors was initiated and resulted in a full response. The patient is for 2 years tumor free with no signs of recurrence. To our knowledge our case report is longest in the world for stage IV CCA treated with dabrafenib + trametinib.

This paper repons the effect of gram parameters and buffer structure on the ILminescence, electrical ano strLctLral character stics of thin (< 2pm)A two-stage SJostrate temperature groffln regime has been oeve oped on the basis of a thermodynam:c consideraton of the growth process, taking 'nto account the additional Gibbs free energy due 10 the strain at the 'nitial growth. Tnis reg'me permits tne grorvtn of GaSb eplayers w:lh a smal Sb/Ga ratio at high substrate temperatures: it provides a greater excaon photoluminescence (PL) intens'ly and Hal mobil'ty (over 5000 cm2 V-' s-' a t 77 K) and improves tne layer quality. The appearance of a free exciton lminescence I:ne (809 meV) in the PL spectra of MBE GaSb/GaAs 's reponed for the frst h e . It is also shown thai a (50 A AISb/50 A GaSb)lo snon-per:od sLperian;ce prevents non-radiat:ve recombination centres and carr:er scanering centres from propagating 'n the top GaSo layer bJt does not bend the misfil oklocaton growing thrOJgh the layer from the GaSblGaAs interface.

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New criteria of radical procedure are presented. The last reflects the concept of dependence of 'pure' surgical edge from not only presence or absence of tumor cells in cut-off plane but also from important morphological features of tumor.

The experimental results of use of a thermoemission cathode as the cathode compensator when working with the Hall electroreactive thruster are presented. The operation particularities of the thruster with the thermoemission cathode are investigated, and the technical requirements for the cathodes in use are adjusted. Data making it possible to specify the technical requirements on the power supplies for the Hall reactive thrusters (HRTs) are obtained. The study of the discharge ignition process in the crossed fields inside the Hall electroreactive thruster shows that, at the moment of ignition, the total discharge current may exceed by 10-20 times that of the stationary regime; here, the value and the duration of the current "spike" depend directly on the emissive ability of the cathode compensator. The influence of the magnetic field value in the accelerator channel on the ignition potential is discovered.