New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinoma management

Kovalenko, Yu. A.; Vishnevsky, V.; Чжао, А. В.; Zharikov, Yu. O.

doi:10.17116/hirurgia201884

Cited by 2 publications

(4 citation statements)

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“…As surgical treatment is prone to complications and seriously affects the quality of life of patients, in the postoperative period, it is necessary to strengthen the rehabilitation of patients with CCA from psychological and dietary perspectives (23,24). Following CCA surgery, patients should follow their doctor's advice and (25). However, the majority of CCA patients are diagnosed at an advanced stage, when surgery is not possible (26).…”

Section: Discussionmentioning

confidence: 99%

Effects of propofol on human cholangiocarcinoma and the associated mechanisms�

et al. 2018

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Cholangiocarcinoma (CCA) is the most common type of biliary duct malignancy. Propofol is a fast-acting intravenous anesthetic, which also exerts an anti-cancer effect. The aim of the current study was to explore the effects of propofol on human CCA and the associated mechanisms in vitro. The results indicated that as concentration (0, 1, 5 and 10 µg/ml) of propofol and treatment time (24, 48 and 72 h) increased, the cell inhibition rate of human CCA QBC939 cells increased. Furthermore, treatment with various concentrations of propofol for 48 h resulted in a decrease in migration and invasion capacity in QBC939 cells. Propofol also induced the apoptosis of QBC939 cells and cell cycle arrest in G1 phase. Propofol treatment increased the expression level of Bax and decreased that of Bcl-2. In addition, the effects of propofol on gene expression were evaluated, including Wnt3α, β-catenin, Snail1 and c-myc in the Wnt/β-catenin signaling pathway. It was identified that as the concentration of propofol increased, the expression of these genes decreased. In conclusion, the current results indicate that propofol is a promising therapeutic agent for the treatment of CCA.

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Section: Discussionmentioning

confidence: 99%

Effects of propofol on human cholangiocarcinoma and the associated mechanisms�

et al. 2018

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“…So far there are only few studies presenting the operative management and outcomes of patients with curative-intent surgery for PHC in East Europe (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Discussion Discussionmentioning

confidence: 99%

“…The aforementioned studies included usually small series of patients (i.e., 1 to 44 patients), except for one Romanian (7) and one Russian study (9).…”

Section: Discussion Discussionmentioning

confidence: 99%

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Operative Management and Outcomes of 150 Patients with Curative-intent Surgery for Perihilar Cholangiocarcinomas: A Single Institute East European Perspective

Dumitraşcu¹,

Brasoveanu²,

Stroescu³

et al. 2018

SGO

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Introduction:The knowledge of current approach and outcomes of curative-intent surgery for perihilar cholangiocarcinoma (PHC) has been highlighted in studies of the literature including mainly East Asian and Western patients. Thus, papers presenting the curative-intent surgery in East Europe are scarce. The study aims to present the operative management and outcomes of curative-intent surgery for PHC in an East European institutional experience. Patients and methods: The data of all patients with curative-intent surgery for PHC between 1996 and 2017 were retrospectively reviewed from a prospective maintained electronic database at our Department of Surgery. The assessment was made for the operative management and early and late outcomes. Results: Liver resections were performed in 80.7% of patients, with caudate lobectomies in 64.7% of cases. Vascular resections were performed in 19.4% of patients. Preoperative biliary drainage was performed in 26% of patients. Negative resection margins were obtained in 76.7% of patients. Overall and severe morbidity rates were 57.3% and 24%, respectively. Postoperative bile leak, liver failure and hemorrhage rates were 31.3%, 24.7% and 10%, respectively. The 90-day mortality rate was 6%. The median overall and disease-free survival times were 26 months and 21 months, respectively. Conclusion: The standard approach for curative-intent surgery for PHC implies bile duct resection associated with major hepatectomies, including caudate lobectomy. Expertise in referral surgical centers of East Europe is associated with morbidity, mortality and overall survival rates comparable with those reported in Western centres, despite low rate of preoperative biliary drainage and no use of portal vein embolization. Improvements of preoperative optimization with portal vein embolization and biliary drainage may potentially lead to better early and long-term outcomes.

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New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinoma management

Abstract: New criteria of radical procedure are presented. The last reflects the concept of dependence of 'pure' surgical edge from not only presence or absence of tumor cells in cut-off plane but also from important morphological features of tumor.

Cited by 2 publications

References 20 publications

Effects of propofol on human cholangiocarcinoma and the associated mechanisms�

Effects of propofol on human cholangiocarcinoma and the associated mechanisms�

Operative Management and Outcomes of 150 Patients with Curative-intent Surgery for Perihilar Cholangiocarcinomas: A Single Institute East European Perspective

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