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A convenient synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidine was carried out by the reaction of various ketene dithioacetals with 5-amino 1,2,4-triazole in methanol in presence of sodium methoxide. The newly synthesized compound were characterized by 1H NMR, 13 C NMR, IR, MS, elemental analysis and screened for their antimicrobial activity against various strains of bacteria and fungi.

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Various pyrimidine derivatives are well known for their different pharmaceutical applications. The n-butyl 4-(3, 4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate (n-butyl THPM) was synthesized by using n-butylacetoacetate. The n-butyl acetoacetate was obtained by transesterification of ethyl acetoacetate with n-butyl alcohol using Biginelli condensation. The synthesized powder was used to obtain the nanoparticles of n-butyl THPM by using water/oil microemulsion technique. The average particle size was calculated from the powder XRD pattern by applying Scherrer's formula. The nanoparticles of n-butyl THPM were observed by Transmission Electron Microscope (TEM). The diameter of the nanoparticles varied from 15 nm to 65 nm. The nanoparticles were also characterized by FT–IR spectroscopy, TG–DTA–DSC and mass spectroscopy. The n-butyl THPM nanoparticles were stable up to 280°C. Thermodynamic and kinetic parameters of decomposition were obtained by applying Coats and Redfern relation to the thermogram. The dielectric study was carried out in the frequency range of 50 Hz to 5 MHz. The dielectric constant, dielectric loss and ac conductivity decreased as the frequency of applied field increased.

A series of novel highly substituted pyrimidines bearing furanyl thiazole nucleous have been synthesized. In which reaction of guanidine nitrate with ketene dithioacetals 3c produced substituted pyrimidines 4d which further treated with various aromatic aldehydes to afford title compounds 5(a-t). The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.

We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-one using 2-Amino-4’-fluorobenzophenone as initial stating material. The small library of N-alkylation and C-3 benzylidene derivatives have been synthesized by base catalyzedreaction of 5-(4-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one (3) nucleus with various alkyl halides and aromatic aldehydes respectively.

We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno

A series of novel 5-(2-bromophenyl)-N-cyclohexyl-2-(methylthio)-6-nitro-7-phenyl-4,7-dihydropyrazolo [1,5-a] pyrimidine-3-carboxamides were synthesized by a one-pot reaction of 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide, 1-(2-bromophenyl)-2-nitroethanone and aryl aldehydes in the presence of boric acid in water at refluxing temperature. Structures of compounds were demonstrated by Fourier transform infrared, 1H NMR, 13C NMR and elemental analysis. The advantages of this method are mild reaction condition, good yields, and operational simplicity.