Synthesis of Novel Highly Substituted Pyrimidines Bearing Furanyl Thiazole Nucleous

Abstract

A series of novel highly substituted pyrimidines bearing furanyl thiazole nucleous have been synthesized. In which reaction of guanidine nitrate with ketene dithioacetals 3c produced substituted pyrimidines 4d which further treated with various aromatic aldehydes to afford title compounds 5(a-t). The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.

Synthesis, Characterization, Acute Toxicity and Investigation of the new Pyrimidine Derivative as antihyperlipidemic activity on Male Mice.

“…The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan (2). The first pyrimidine derivative to be isolated was alloxan in 1818 by Brugnatelli, oxidizing uric acid with nitric acid (3). Methoprim, which is one of the pyrimidine derivatives, is one of the effective medicines against many bacterial infections, including urinary tract infection and pneumonia.…”