Synthesis and QSAR Studies of 4-Substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents

One-Pot Synthesis of Some Novel N-Aryl-1,4-Dihydropyridines Derivatives Bearing Nitrogen Mustard

“…The systematic structural modification of the 1,4-DHP ring yields different compounds used in the treatment of TB and cancer [3]. Recently, studies showed that 3,5-dicarbamoyl derivatives of 1,4-dihydropyridine (DHP) with lipophilic groups have considerable antitubercular activity against M. tuberculosis H37Rv [4][5][6][7][8]. It was also observed that esters or substituted isosters of pyridine and pyrazine carboxylic acids (such as tetrazoles) have been more active than the parent acids especially against resistant strains.…”

One-pot, multicomponent synthesis of symmetrical Hantzsch 1,4-dihydropyridine derivatives using glycerol as clean and green solvent

“…In the present scenario many representatives have been commercialised such as nifedipine [3], felodipine [4], nicardipine [5], amlodipine [6] and even more have made their presence felt in the market [7] in the treatment of angina and hypertension. The activity profiles of 1,4-DHP's were further expanded as they were detected to possess anti-tumor [8], antiinflammatory [9], anticonvulsant activity [10], antitubercular activity [11,12] cerebral antischemic activity in the treatment of Alzheimer's disease, PAF-acether antagonists [13]. Invention and execution of various new methodologies have engendered for the synthesis of symmetrical 1,4-DHP's.…”

Process optimization and eco-friendly/greener synthesis of some n-aryl/heteryl acetoacetamides

“…In particular, they play key role as intermediates in the synthesis of pyridines and pyrimidines (Dyachenko, 2005;Habashi et al, 1986;Lebed et al, 2012;Kumar et al, 2009;Riad et al, 1989;Sadek et al, 2011;Viale et al, 2011;Yadav et al, 2003;Yadav et al, 2011). They are prepared by the two component reaction of alkyl acetoacetate and different aromatic /hetero aromatic amines (Desai et al, 2001). Reaction of acetoacetamides with various aldehydes in presence of ammonia source yield different derivatives of pyridines and pyrimidines having different pharmacological activities like antibacterial, antitubercular (Sirisha et al, 2011), anticancer (Sirisha et al, 2010), antioxidant (Velena et al, 1999) etc.…”