Two Step One-Pot Synthesis of Novel 5-(4-Fluorophenyl)-1<i>H</i>-Beno[e][1,4]Diazepin-2(3<i>H</i>)-One and it’s Base Catalyzed Transformation to <i>N</i>-Alkyl and C-3 Arylidene Derivatives

Abstract

We have demonstrated two step one-pot synthesis of novel 5-(4-Fluorophenyl)-1H-Beno[e][1,4]Diazepin-2(3H)-one using 2-Amino-4’-fluorobenzophenone as initial stating material. The small library of N-alkylation and C-3 benzylidene derivatives have been synthesized by base catalyzedreaction of 5-(4-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one (3) nucleus with various alkyl halides and aromatic aldehydes respectively.