Sporotrichosis is a mycosis caused by Sporothrix schenckii. The most affected animal is the cat; it has played an important role in the zoonotic transmission of this disease, especially in Rio de Janeiro, Brazil, since 1998. In order to evaluate the treatment of feline sporotrichosis with potassium iodide, an observational cohort was conducted in 48 cats with sporotrichosis at Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz. All cats received potassium iodide capsules, 2.5 mg/kg to 20 mg/kg q24h. The cure rate was 47.9%, treatment failure was 37.5%, treatment abandonment was 10.4% and death was 4.2%. Clinical adverse effects were observed in 52.1% of the cases. Thirteen cats had a mild increase in hepatic transaminase levels during the treatment, six of them presented clinical signs suggestive of hepatotoxicity. Compared to previous studies with itraconazole and iodide in saturated solution, potassium iodide capsules are an alternative for feline sporotrichosis treatment.
The aim of this study was evaluate changes in the cholinesterase activity in blood, lymphocytes and serum of rats infected with Leptospira interrogans serovar Icterohaemorrhagiae ('L. icterohaemorrhagiae'). Sixty adult Wistar rats were divided into six groups of 10 animals: three control groups and three test groups. The animals from the test groups were intraperitoneally inoculated with 1 ml medium containing 1¾10 8 leptospires. The activity of acetylcholinesterase in blood and butyrylcholinesterase in serum increased on days 5 (P,0.05) and 30 (P,0.021) post-infection, respectively. A decrease in lymphocyte count was observed on days 15 (P,0.01) and 30 post-infection (P,0.05). On day 15 post-infection, acetylcholinesterase activity (P,0.001) in lymphocytes decreased in infected rats. However, on day 30 post-infection there was an increase in acetylcholinesterase activity in lymphocytes. In conclusion, our results showed that the activity of enzymes of the cholinergic system in the total blood, lymphocytes and serum is altered as a result of inflammation caused by infection with L. icterohaemorrhagiae. The possible causes of these alterations will be discussed in this paper.
The measurement of serum parameters during general anesthesia procedures are subject to variations due to differences in protocol, splenic storage, and by the instituted fluid therapy. The aim of this study was to assess the hematocrit changes promoted by controlled fluid therapy and general anesthesia. Six mongrel female dogs underwent an anesthetic protocol with acepromazine (0.03 mg kg -1 ) and tramadol (5 mg kg -1 ) for premedication, induction with propofol (3 mg kg -1 ), and maintained with isoflurane and mechanical ventilation for 120 minutes. After induction, they were infused with 10 ml kg hr -1 of Ringer's lactate solution. Hematocrit measurements were performed from the start until 72 hours from anesthesia and evaluated statistically to check if there were significant changes over time. The fluid therapy, the acepromazine and propofol in the anesthetic protocol promotes a significant reduction of hematocrit up to four hours after general anesthesia. Key words: Packed cell volume, crystalloids, acepromazine, propofol, bleeding
ResumoA mensuração de parâmetros séricos durante procedimentos dependentes de anestesia geral são passíveis de variações devido a diferenças do protocolo utilizado, armazenamento esplênico e também da fluidoterapia instituída. O objetivo deste trabalho foi avaliar o hematócrito buscando evidenciar as alterações flutuantes promovidas por fluidoterapia controlada e anestesia geral em cães submetidos a ovariohisterectomia laparoscópica. Seis cadelas sem raça definida foram submetidas a um protocolo anestésico com acepromazina (0,03 mg kg -1 ) e tramadol (5,0 mg kg -1 ) como medicação pré-anestésica, indução com propofol (3,0 mg kg -1 ) e mantidas com isoflurano e ventilação mecânica durante 120 minutos. Após a indução, receberam a infusão de 10,0 ml kg hr -1 de solução Ringer com lactato. Foram realizadas aferições de hematócrito do início (ou antes?) até 72 horas após a anestesia, sendo avaliadas 1 Discente, Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná, UFPR, Curitiba, PR. Brasil.
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