Secnidazole for the treatment of giardiasis in naturally infected cats

Silva, Aleksandro S. Da; Castro, Verônica Souza Paiva; Tonin, Alexandre A.; Brendler, Sabrina; Costa, Márcio Machado; Jaques, Jeandre A.; Bertoletti, Bianca; Zanette, Régis A.; Raiser, Alceu Gaspar; Mazzanti, Cinthia M.; Lopes, Sonia T.A.; Monteiro, Sílvia González

doi:10.1016/j.parint.2011.06.024

Cited by 13 publications

(13 citation statements)

References 27 publications

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“…The efficacy of secnidazole in lambs is comparable to what has been described in cats naturally infected with giardiasis, in which an oral single dose of 30 mg/kg resulted in 100 % efficacy, as no cysts were found in faeces after treatment (18). In the present study secnidazole treatment significantly reduced the cyst excretion calculated based on geometric mean by 99.98% on day 10 after the start of the treatment, resulting in a significant reduction (p<0.001) in cyst excretion in secnidazole treatment group.…”

Section: 98%supporting

confidence: 66%

“…Similar to surveys among humans, parasitological eradication rate of 100% was obtained after single-dose treatment with secnidazole in cats infected with G. duodenalis (18). Currently no drug is licensed or FDA approved for the treatment of giardiasis in ruminants.…”

Section: Materiales Y Métodossupporting

confidence: 52%

“…Al igual que en los exámenes entre seres humanos, se obtuvo una tasa de erradicación parasitológica del 100% después del tratamiento con una dosis única de secnidazol en gatos infectados con G. duodenalis (18). Actualmente ningún medicamento está autorizado o aprobado por la FDA para el tratamiento de la giardiasis en rumiantes.…”

Section: G I a R D I A D U O D E N A L I S ( G L A M B L I A A N D unclassified

“…La eficacia del secnidazol en corderos es comparable con aquella descrita en gatos infectados naturalmente con giardiasis, en los cuales una única dosis oral de 30 mg/kg produjo una eficacia del 100%, ya que no se encontraron quistes en las heces después del tratamiento (18). En el presente estudio, el tratamiento con secnidazole redujo significativamente la excreción de quistes calculada en base a la media geométrica en un 99.98% el día 10 después del inicio del tratamiento, lo tiene como resultado una reducción significativa (p<0.001) en la excreción de quistes en el grupo tratado con secnidazol.…”

Section: 98%unclassified

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Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs

et al. 2014

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Objective. The purposes of this study were to determine whether secnidazole administered at a single dose of 10 mg/kg, orally, lessens or eliminates Giardia cyst shedding, and to validate the benefit of secnidazole treatment on clinical signs and faecal consistency in lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 12 weeks of age lambs were selected and randomly assigned into two groups based on placebo (group C, n=7 untreated control group) or treatment (group S, n=10 lambs treated with a single dose of secnidazole at 10 mg/kg). Results. On days 0 and 10, before and after treatment, respectively, reduction in cyst excretion was determined. The faecal consistency and general health were recorded at each sampling day. Conclusions. During the study there was a high (99.98%) reduction in cyst excretion in the secnidazol treatment group compared to the positive control group on day 10, resulting in a significant (p<0.001) reduction, making secnidazole highly effective treatment option.Key words: Clinics, evaluation, lamb, secnidazol (Source: CAB). RESUMENObjetivo. El objetivo de este estudio fue determinar si la administración oral de una dosis única de secnidazol de 10mh/kg reduce o elimina la presencia de quistes de Giardia y validar el beneficio del tratamiento con secnidazol en los signos clínicos y la consistencia fecal de corderos infectados naturalmente con Giardia duodenalis. Materiales y métodos. Se seleccionaron corderos destetados de 12 semanas de edad que fueron asignados al azar a dos grupos con base a placebo (grupo C, n=7, grupo de control sin tratar) o tratamiento (grupo S, n=10 corderos con tratamiento de dosis única de secnidazol de 10 mg/kg). Resultados. En los días 0 y 10, antes y después del tratamiento, respectivamente, se determinó una merma en la excreción de quistes. La consistencia de la materia fecal y el estado general de salud fue registrado en cada muestreo diario. Conclusiones. Durante el estudio hubo una alta reducción en la excreción de quistes (99.98%) en el grupo tratado con secnidazol comparado con el grupo control positivo en el día 10, resultando en una disminución significativa (p<0.001), haciendo del tratamiento con secnizadol una opción altamente efectiva.

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Section: 98%supporting

confidence: 66%

Section: Materiales Y Métodossupporting

confidence: 52%

Section: G I a R D I A D U O D E N A L I S ( G L A M B L I A A N D unclassified

Section: 98%unclassified

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Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs

et al. 2014

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“…El secnidazol es utilizado actualmente por la industria farmacéutica para tratar la giardiasis, la amebiasis y la tricomoniasis en humanos; que tiene la principal ventaja de ser una dosis única. Actualmente, los investigadores están evaluando los resultados en mascotas y animales de producción debido a los resultados obtenidos con dosis únicas (9,10,11).…”

Section: Introductionunclassified

Uso de secnidazol y homeopatía para el control de giardiasis en perros

et al. 2020

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Dogs with Giardia infections have diarrhea that persists for days, even after treatment. We managed canine giardiasis using two distinct approaches: treatment with the antiprotozoan secnidazole alone; and secnidazole plus a homeopathic product that is indicated for control of diarrhea in dogs. Treatment I: Ten beagle dogs showed clinical signs of severe diarrhea. Their feces revealed large numbers of cysts consistent with Giardia sp. Therefore, we treated the dogs with secnidazole (10 mg/kg, single dose) given orally. Five days after treatment, all dogs were negative for Giardia spp. Treatment II: Three months later, the same ten Beagles again presented with diarrhea. Feces were collected, revealing Giardia sp. in all dogs. This time, we treated them with an antiprotozoan (secnidazole, 10 mg/kg dose) combined with a commercial homeopathic drug for diarrhea control (3 g dose/animal at 12 h interval). We found that three to five homeopathic doses were needed to achieve normal fecal scores in all dogs. After 5 days of treatment, stool samples had normal consistency and were negative for Giardia. This is the first record of using secnidazole to control canine giardiasis associated with homeopathic drugs to prevent diarrhea.

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