Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs

Abstract

Objective. The purposes of this study were to determine whether secnidazole administered at a single dose of 10 mg/kg, orally, lessens or eliminates Giardia cyst shedding, and to validate the benefit of secnidazole treatment on clinical signs and faecal consistency in lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 12 weeks of age lambs were selected and randomly assigned into two groups based on placebo (group C, n=7 untreated control group) or treatment (group S, n=10 lambs treated with a single dose of secnidazole at 10 mg/kg). Results. On days 0 and 10, before and after treatment, respectively, reduction in cyst excretion was determined. The faecal consistency and general health were recorded at each sampling day. Conclusions. During the study there was a high (99.98%) reduction in cyst excretion in the secnidazol treatment group compared to the positive control group on day 10, resulting in a significant (p<0.001) reduction, making secnidazole highly effective treatment option.Key words: Clinics, evaluation, lamb, secnidazol (Source: CAB). RESUMENObjetivo. El objetivo de este estudio fue determinar si la administración oral de una dosis única de secnidazol de 10mh/kg reduce o elimina la presencia de quistes de Giardia y validar el beneficio del tratamiento con secnidazol en los signos clínicos y la consistencia fecal de corderos infectados naturalmente con Giardia duodenalis. Materiales y métodos. Se seleccionaron corderos destetados de 12 semanas de edad que fueron asignados al azar a dos grupos con base a placebo (grupo C, n=7, grupo de control sin tratar) o tratamiento (grupo S, n=10 corderos con tratamiento de dosis única de secnidazol de 10 mg/kg). Resultados. En los días 0 y 10, antes y después del tratamiento, respectivamente, se determinó una merma en la excreción de quistes. La consistencia de la materia fecal y el estado general de salud fue registrado en cada muestreo diario. Conclusiones. Durante el estudio hubo una alta reducción en la excreción de quistes (99.98%) en el grupo tratado con secnidazol comparado con el grupo control positivo en el día 10, resultando en una disminución significativa (p<0.001), haciendo del tratamiento con secnizadol una opción altamente efectiva.

The efficacy of chloroquine treatment against naturally occuring Giardia duodenalis infection in lambs

“…Fecal material was mixed through fifteen mL of ZnSO 4 solution (33%) and strained onto centrifuge tubes. Afterwards sample was subjected to centrifuge at 880 x g for 5 minutes as described (20), and to those of similarly to what have been reported elsewhere (14). Following centrifugation, a limited portion of the fecal mixture was collected and emitted on a microscope slide containing Lugol iodine, which was covered by a slip.…”

“…The traditional anti-Giardial treatment in sheep includes the usage of fenbendazole (10,11), albendazole (12), secnidazol (13,14) and paromomycin (15) resulting in a clinical benefit in treated lambs. Contrarily fenbendazole and albendazole need to be adminestered in multiple doses, besides paramomycin is expensive.…”

“…El tratamiento tradicional anti-giardial en ovejas incluye el uso de fenbendazol (10,11), albendazol (12), secnidazol (13,14) y paromomicina (15) lo que resulta en un beneficio clínico para los corderos tratados. Por el contrario, el fenbendazol y el albendazol tienen que administrarse en dosis múltiples, mientras que la paramomicina es costosa.…”

Secnidazol Treatment to Improve Milk Yield in Sheep with Giardiasis

“…There was a high (99.98%) and significant reduction (P<0.001) in cyst excretion in the secnidazol treatment group in contrast to the positive control group on day 10, after therapy, suggesting the latter drug a highly effective treatment option (Ural et al, 2014).…”

“…AntiGiardial therapy within secnidazole has been the subject of various research articles in humanbeing (Di Prisco et al, 2000;Escobedo et al, 2003;Almirall et al, 2011). Besides in line with the purpose of this study, the efficacy of secnidazol against Giardiasis in lambs ( Ural et al, 2014) and Balantidiasis in cattle (Tarrar et al, 2008;Bilal et al, 2009) Disinfection by use of a product containing quaternary ammonium was performed prior to trial, for elimination of probable existing environmental contamination.…”