Cholinesterases as markers of the inflammatory process associated oxidative stress in cattle infected by Babesia bigemina

Doyle, Rovaina Laureano; Silva, Aleksandro S. Da; Oliveira, Camila Belmonte; França, Raqueli Teresinha; Carvalho, Fabiano B.; Abdalla, Fátima Husein; Costa, Pauline da; Klafke, Guilherme Marcondes; Martins, João Ricardo; Tonin, Alexandre A.; Castro, Verônica Souza Paiva; Santos, Franklin Gerônimo Bispo; Lopes, Sonia T.A.; Andrade, Cínthia Melazzo de

doi:10.1016/j.cimid.2016.03.002

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…Acutely lowered AChE activity was seen in brain injury patients with chronic cognitive symptoms. Numerous studies have demonstrated a dynamic decline in AChE activity in the brain following brain damage because AChE is an important factor in maintaining AChE levels (Doyle et al 2016 ). In the present study, rats exposed to PD showed a decrease in AChE activity but for the first time when TNG was co-administered, this effect was prevented.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis

A.Sedik

Elgohary

2023

Inflammopharmacol

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Potassium dichromate (PD) is an environmental xenobiotic commonly recognized as teratogenic, carcinogenic, and mutagenic in animals and humans. The present study was conducted to investigate the role of tangeretin (TNG) as a neuro-protective drug against PD-induced brain injury in rats. Thirty-two male adult Wistar rats were blindly divided into four groups (8 rats/group). The first group received saline intranasally (i.n.). The second group received a single dose of PD (2 mg/kg, i.n.). The third group received TNG (50 mg/kg; orally), for 14 days followed by i.n. of PD on the last day of the experiment. The fourth group received TNG (100 mg/kg; orally) for 14 days followed by i.n. of PD on the last day of the experiment. Behavioral indices were evaluated 18 h after PD administration. Neuro-biochemical indices and histopathological studies were evaluated 24 h after PD administration. Results of the present study revealed that rats intoxicated with PD induced- oxidative stress and inflammation via an increase in malondialdehyde (MDA) and a decrease in nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and glutathione(GSH) levels with an increase in brain contents of tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6). Pre-treatment with TNG (100 mg/kg; orally) ameliorated behavior, cholinergic activities, and oxidative stress and decreased the elevated levels of pro-inflammatory mediators; TNF-α and IL-6 with a decrease in brain content of chromium residues detected by Plasma–Optical Emission Spectrometer. Also, the histopathological picture of the brain was improved significantly in rats that received TNG (100 mg/kg). Additionally, TNG decreased caspase-3 expression in the brain of PD rats. In conclusion, TNG possesses a significant neuroprotective role against PD-induced acute brain injury via modulating the Nrf2 signaling pathway and quenching the release of inflammatory mediators and apoptosis in rats. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis

A.Sedik

Elgohary

2023

Inflammopharmacol

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“…Overall, this can be explained mainly by the fact that both groups of animals were in apparent good health. Indeed, the majority of the studies carried out involved SO most often in pathological (Bozukluhan et al, 2018;Doyle et al, 2016) or physiological situations where the transition period chosen as the reference period in dairy cows (Colakoglu et al, 2017;Folnozic et al, 2015;Tanh et al, 2011) or the comparison between groups supplemented with antioxidants compared to those not supplemented (Abuelo et al, 2016a;Haser and Furll, 2015;Kahlon and Singh, 2003). Although, in cows the mobilisation of fat reserves can create a dysfunction of the mitochondrial metabolism, which will lead to an increase in oxidative stress especially in early lactation (Abuelo et al, 2016a;Bernabucci et al, 2005), in heifers the negative energy balance and metabolic stress are of lesser importance when the markers of metabolic stress are compared (Pryce et al, 2004).…”

Section: Articlementioning

confidence: 99%

“…The oxidative stress has been postulated to play a role in reproduction and might compromise animal welfare and health and any clinical situations in dairy cows (Vedovatto et al, 2019). Oxidative stress is described in lameness (Abuelo et al, 2016b), foot-and-mouth disease (Nath et al, 2014), Brucellosis (Bozukluhan et al, 2018), in hemolytic infections during Babesiosis in cattle (Doyle et al, 2016) and in calves (Salem et al, 2016). Furthermore, reactive oxygen species affects multiple physiological processes from oocyte maturation to fertilization, embryonic survival and development, and pregnancy maintenance (Vedovatto et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Plasma Oxidative Stress Biomarkers and Metabolic Parameters of Dairy Heifers: Relationship with Success at First Service

et al. 2022

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First insemination success is considered as good indicator of heifer fertility to ensure renewal of dairy herds. The objective of this study was to determine the relationship between first insemination success and biomarkers of oxidative stress (OS). A total of 25 heifers were divided into two groups according to their success at first insemination: group FS+ (heifers that were pregnant at first service, n = 14) and group FS- (heifers that were not pregnant at first service, n = 11). The serum of these two groups were analyzed for malondialdehyde (MDA), glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), myeloperoxidase (MPO), nitric Oxide (NO) and superoxide dismutase (SOD) as oxidative stress biomarkers and biochemical parameters. Heifers in the group FS+ showed no significant difference in all OS parameters compared to heifers in the group FS-. The OS parameters showed almost similar values in both groups except for GST and CAT where the difference was at the limit of significance. The plasma concentration of OS biomarkers assessed in our study were not related to first service success in heifers. Further studies are needed to clarify the role of oxidative status in the reproductive performance of heifers.

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“…Species affecting animals are: Babesia bigemina, Babesia major, Babesia divergens and Babesia bovis that infect cattle [44,[48][49][50][51]; Babesia ovis and Babesia motasi cause infections in sheep [44,52,53]; and Babesia equi and Babesia caballi cause infections in horses [44,54].…”

Section: Babesiamentioning

confidence: 99%

Genomics of Apicomplexa

Martínez-Ocampo¹

2018

Farm Animals Diseases, Recent Omic Trends and New Strategies of Treatment

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Apicomplexa is a eukaryotic phylum of intracellular parasites with more than 6000 species. Some of these single-celled parasites are important pathogens of livestock. At present, 128 genomes of phylum Apicomplexa have been reported in the GenBank database, of which 17 genomes belong to five genera that are pathogens of farm animals: Babesia, Theileria, Eimeria, Neospora and Sarcocystis. These 17 genomes are Babesia bigemina (five chromosomes), Babesia divergens (514 contigs) and Babesia bovis (four chromosomes and one apicoplast); Theileria parva (four chromosomes and one apicoplast), Theileria annulata (four chromosomes), Theileria orientalis (four chromosomes and one apicoplast) and Theileria equi (four chromosomes and one apicoplast); Eimeria brunetti (24,647 contigs), Eimeria necatrix (4667 contigs), Eimeria tenella (12,727 contigs), Eimeria acervulina (4947 contigs), Eimeria maxima (4570 contigs), Eimeria mitis (65,610 contigs) and Eimeria praecox (53,359 contigs); Neospora caninum (14 chromosomes); and Sarcocystis neurona strains SN1 (2862 contigs) and SN3 (3191 contigs). The study of these genomes allows us to understand their mechanisms of pathogenicity and identify genes that encode proteins as a possible vaccine antigen.

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Cholinesterases as markers of the inflammatory process associated oxidative stress in cattle infected by Babesia bigemina

Cited by 12 publications

References 22 publications

Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis

Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis

Assessment of Plasma Oxidative Stress Biomarkers and Metabolic Parameters of Dairy Heifers: Relationship with Success at First Service

Genomics of Apicomplexa

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