Malignant pleomorphic parotid adenoma with inflammatory cutaneous metastasis

Soler, Elena; Borrego, Leopoldo; Hbrnandez-Santana, J.; Castro, Verônica Souza Paiva; Rodriguez, J. C. Vicente; Hernández-Hernández, Betsabé

doi:10.1111/j.1365-2133.1996.tb07874.x

Cited by 7 publications

(15 citation statements)

References 5 publications

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“…This type of metastasis is frequently observed in patients with breast carcinomas 59 . Also, it can be encountered during the course of carcinomas of the esophagus, larynx, stomach, pancreas, lung, parotid, tonsils, ovary, uterus, prostate, rectum and salivary glands 16,40,112,137–139 . En cuirasse metastatic carcinoma is characterized by a diffuse morphea‐like induration of the skin 126 .…”

Section: Clinical Presentations Of the Skin Metastasesmentioning

confidence: 99%

Skin metastasis: a pathologist's perspective

2010

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Skin metastasis is defined as the spread of malignant cells from a primary malignancy to the skin. It is one manifestation of systemic spread of cancer. The tumor cells originate either from an internal malignancy or from a primary skin cancer. This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The regional distribution of the skin metastasis, although not always predictable, is related to the location of the primary malignancy and the mechanism of metastatic spread. The relative frequency of skin metastasis correlates with the type of primary cancer, which occurs in each sex. For instance, lung and breast carcinomas are the most common primaries that send skin metastasis in men and women, respectively. The head and neck region and the anterior chest are the areas of greatest predilection in men. The anterior chest wall and the abdomen are the most commonly involved sites in women. Skin metastases usually appear as non-specific groups of discrete firm painless nodules that emerge rapidly without any explanation. They vary in size from so tiny as to be of 'miliary lesions' to as large as 'Hen's egg size'. Some skin metastasis may mimic specific dermatological conditions such as cutaneous cyst, dermatofibroma, pyogenic granuloma, hemangioma, papular eruptions, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, cellulitis and erysipelas. Histologically, the skin metastases usually show features reminiscent of the primary malignancy, but with variable degrees of differentiation. Molecularly, skin metastasis is an organized, non-random and organ-selective process orchestrated by interaction among several heterogeneous molecules, which are largely unknown. Metastasis to the skin is often a pre-terminal event that heralds poor outcome.

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Section: Clinical Presentations Of the Skin Metastasesmentioning

confidence: 99%

Skin metastasis: a pathologist's perspective

2010

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“…As mentioned in the introduction, multiple database searching revealed only nine cases of skin metastasis from malignant tumours of the parotid gland (Table 2). 3–11 These nine patients were aged between 39 and 81 years (mean 62 years). Eight of the nine patients underwent treatment of the primary tumour, while the remaining patient was untreated until skin metastases appeared on the abdomen.…”

Section: Discussionmentioning

confidence: 99%

“…Eight of the nine patients underwent treatment of the primary tumour, while the remaining patient was untreated until skin metastases appeared on the abdomen. Total parotidectomy was performed as initial treatment in all eight patients, with radical neck dissection being performed in three of these at the same time 4,7,8 . The diagnosis of these primary tumours included adenoid cystic carcinoma, ductal carcinoma, malignant mixed tumour and adenocarcinoma, not otherwise specified.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous metastases from parotid carcinomas are extremely rare. According to multiple database searching on Ovid, SpringerLink, Elsevier SDOL and PubMed, only nine cases of cutaneous metastases from parotid malignancies have been reported since 1977 3–11 . However, there are no published reports of cutaneous metastasis of myoepithelial carcinoma of the parotid gland.…”

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Cutaneous metastasis from a parotid myoepithelial carcinoma: a case report and review of the literature

et al. 2008

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Myoepithelial carcinoma of the parotid gland is a rare salivary gland tumour, and its distant cutaneous metastasis has not been reported to date. Here, we report a case of myoepithelial carcinoma of the left parotid gland, which had metastasised to the skin of the right thorax after parotidectomy and radiotherapy. Diagnosis of the primary and metastatic tumour was based on the clinical findings and was confirmed by immunohistochemistry. A literature review of the clinical features of the skin metastases of parotid malignancies and their related pathological mechanisms is included in this case study. It was noted that myoepithelial carcinoma of the parotid gland has the potential to develop distant skin metastasis, which may be indicative of widespread dissemination and poor prognosis. Attention should be paid to initial treatment of the primary tumour and to emerging cutaneous masses whose location is distant from the primary tumour during follow up.

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“…Upon the review of previous reports, the majority cases of carcinoma erysipelatoides have appeared after chemotherapy, radiotherapy, lymphadenectomy or tumour excision surgery (10–13). The skin eruption in our case is also found after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin

et al. 2005

International Journal of Clinical Practice

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Carcinoma erysipelatoides, also known as inflammatory metastatic carcinoma, is a rare form of cutaneous metastasis from a malignancy. The characteristic histopathological finding is metastatic tumour cells inside the dermal lymphatic ducts. It is frequently observed in patients with breast carcinoma as well as adenocarcinoma of pancreas, rectum, lung, ovary and parotid gland. We present a 66-year-old man diagnosed to have metastatic squamous cell carcinoma by aspiration cytology from an enlarged neck lymph node and a core biopsy of a left axillary mass. He subsequently received radiotherapy; however, due to intolerance to erythema and swelling on local irradiated skin, radiotherapy was deferred. Skin lesions on upper chest and neck area, consisting of erythematous induration with telangiectasia and tenderness, progressed slowly and were treated as cellulitis. The erythema remained stationary with antibiotic treatment. Skin biopsy shows poorly differentiated squamous carcinoma cells within dermis and dilated dermal vessels.

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Malignant pleomorphic parotid adenoma with inflammatory cutaneous metastasis

Cited by 7 publications

References 5 publications

Skin metastasis: a pathologist's perspective

Skin metastasis: a pathologist's perspective

Cutaneous metastasis from a parotid myoepithelial carcinoma: a case report and review of the literature

Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin

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