Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin

Kj, Yu; He, Lei; Hc, Ho; Lee, J. C.; Chang, Jui-Chi; Hong, Hsiang‐Hsi; Yang, Chengli

doi:10.1111/j.1368-5031.2005.00588.x

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…35 An erysipelas-like presentation, with sharply demarcated erythematous patches and plaques affecting the breast and surrounding skin, has been named carcinoma erysipelatoides (Fig. 35 An erysipelas-like presentation, with sharply demarcated erythematous patches and plaques affecting the breast and surrounding skin, has been named carcinoma erysipelatoides (Fig.…”

Section: Inflammatory Metastatic Breast Carcinomamentioning

confidence: 99%

“…18 Sometimes, these cutaneous metastases appear as purpuric nodules, papules, or plaques on the chest wall, usually continuous with a preexisting surgical scar. 5 Immunostaining with the antibodies against CD31 and podoplanin demonstrates that malignant cells formed solid aggregates only within the lumina of vessels lined by endothelial cells that are positive for CD31 but negative for podoplanin, which identify them as blood vessels 18,35 (Fig. 5 Immunostaining with the antibodies against CD31 and podoplanin demonstrates that malignant cells formed solid aggregates only within the lumina of vessels lined by endothelial cells that are positive for CD31 but negative for podoplanin, which identify them as blood vessels 18,35 (Fig.…”

Section: Telangiectatic Carcinomamentioning

confidence: 99%

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Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Section: Inflammatory Metastatic Breast Carcinomamentioning

confidence: 99%

Section: Telangiectatic Carcinomamentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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“…Carcinoma erysipelatoides, also known as inflammatory metastatic carcinoma, is a rare form of cutaneous metastasis. It is frequently observed in patients with breast carcinoma, but not rare inother kinds of malignancy (pancreas, rectum cancer, lung, ovary, and parotid gland) (5). On the skin, lesions are erythematous, warm, tender patches or plaques with raised, well‐defined margins, resembling erysipelas (hence the term “cancer erysipelatoides”) affecting the breast and the surrounding skin (6).…”

Section: Clinical Aspectsmentioning

confidence: 99%

Cutaneous manifestations of breast carcinoma

Giorgi¹,

Grazzini²,

Alfaioli³

et al. 2010

Dermatologic Therapy

101

152

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The incidence of breast carcinoma cutaneous manifestation in patients with breast carcinoma is 23.9%. The most common sites of breast carcinoma cutaneous manifestation are the chest wall and abdomen, but they can occur at the extremities and in the head/neck region. Due the high incidence of breast carcinoma, these cutaneous manifestations are the most common metastases seen by dermatologists. In clinical practice, cutaneous metastases show a wide range of clinical manifestations. Nodules are the most common presentation, but several other patterns are described below.

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“…To our knowledge, this is the first report of erysipelatoid metastasis deriving from a cutaneous SCC. Recently, a case of carcinoma erysipeloides from SCC of unknown origin that developed after radiotherapy was reported 9 . The majority of cases of carcinoma erysipeloides have appeared after chemotherapy, radiotherapy, lymphadenectomy, or tumor excision surgery 9,10 .…”

mentioning

confidence: 99%

“…Recently, a case of carcinoma erysipeloides from SCC of unknown origin that developed after radiotherapy was reported 9 . The majority of cases of carcinoma erysipeloides have appeared after chemotherapy, radiotherapy, lymphadenectomy, or tumor excision surgery 9,10 . Shedding of the tumor cells after these therapies may be a possible mechanism that leads to the formation of this unusual type of metastasis.…”

mentioning

confidence: 99%