Liposarcoma with perineal hernia in dog

Abstract

Liposarcoma is an uncommon malignant tumor originated in the lipoblasts that usually does not produce metastases, but is locally invasive. The final diagnosis is made by histopathology and wide surgical excision is the treatment. A four years old male Pinscher, weighing 2.8 kg, which was previously submitted to seven therapeutic procedures for hepatoid adenoma, was brought to us. On clinical examination a large, soft consistency and painless tumor on lumbodorsal area, besides perineal hernia, was observed. The CT scan revealed an image of an extensive paravertebral intramuscular tumor, embracing retroperitoneal, pelvic canal and ad-anal region. After surgical resection, the material was sent for histopathological examination which confirmed it was a liposarcoma. Thus, chemotherapy protocol with doxorubicin was established. 12 months after the last application of chemotherapy, the patient shows no signs of tumor recurrence nor metastases.

Surgical management of urethral obstruction secondary to perineal liposarcoma in a dog: a case report

“…Tumours arising from adipose tissue can be classified as benign (lipoma, infiltrative lipoma and angiolipoma) and malignant (liposarcoma) [1]. Liposarcomas can be further characterized as well-differentiated, pleomorphic or myxoid [1].…”

“…Liposarcoma is an uncommon malignant tumour of adipose tissue in dogs [1,2]. Only 0.2 to 0.5% of canine tumours are liposarcomas [2].…”

“…Only 0.2 to 0.5% of canine tumours are liposarcomas [2]. Liposarcomas are locally invasive tumours, but metastasize infrequently [1][2][3][4][5][6][7]. They are reported most commonly in the axial and appendicular regions, [1,3,6,[8][9][10] but some cases of liposarcomas within the viscera have been reported [3,4,[6][7][8][9]11].…”

“…Liposarcomas are locally invasive tumours, but metastasize infrequently [1][2][3][4][5][6][7]. They are reported most commonly in the axial and appendicular regions, [1,3,6,[8][9][10] but some cases of liposarcomas within the viscera have been reported [3,4,[6][7][8][9]11]. In rare cases, these tumours can arise from the bone marrow in dogs, (2)(3)5) resulting in extradural spinal liposarcoma [12] or intradural-extramedullar liposarcoma [13].…”

“…Recommended treatment of liposarcoma is tumour resection with wide surgical margins. (1, 3-4, 8, 11) Complete resection of the tumour with safety margins can be curative [1,8]. However, the invasive growth of liposarcomas can make surgical removal challenging [8].…”