Collagen membrane preparations were manufactured with the aim of enhancing wound healing following periodontal surgery. After crosslinking by various processing methods (with ultraviolet and hexamethylenediisocyanate) and to various extents, two types of collagen (atelocollagen and tendon collagen) were implanted into a dissection site within palatal gingival tissue. The time course of healing responses was investigated histologically. Collagen implantation was found to accelerate fibrous connective tissue attachment to the root surface and inhibit apical migration of the junctional epithelium. Cross-linked atelocollagen was superior in biocompatibility to the other collagen membranes studied.
The present study was performed to investigate the effects on periodontal regeneration in flap surgery of acid conditioning and the application of a collagen solution to the root surface. Bone defects were artificially produced in 4 monkeys by removing cortical bone in an apical direction within 4 mm from the alveolar bone crest, following incision and elevation of the buccal gingiva of the second premolars, first molars and lateral incisors of the maxilla and mandibula. After root planing, the root surface at the bottom of the bone defect was notched. The root surfaces were then subjected to various types of root preparation and divided into (1) a group given topical application of collagen solution following acid conditioning, (2) a group given topically applied collagen solution, (3) a group given acid conditioning and (4) controls. The animals were sacrificed 3 or 6 weeks after surgery and histopathologically examined. The results indicated that the method of applying collagen solution to the root surface after acid conditioning in flap surgery promoted suppression of epithelial migration and new cementum formation more effectively than the conventional method of preparation using acid conditioning alone.
The purpose of this study is to reconsider the attachment pattern and to evaluate the effects of Guided Tissue Regeneration (GTR) with Biodegradable collagen membrane (Tissue GuideTM) and enamel matrix protein (EMDOGAIN (R)) applied to experimental periodontal bone defects. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects were created measuring 5 mm in width and 5 mm in height. The experimental bone defects were treated by four different methods: (1) flap operation (control) ; (2) GTR with biodegradable collagen membrane (Tissue GuideTM) (T group) ; (3) applying enamel matrix protein (EMDOGAIN (R)) (E group) ; (4) GTR with Tissue GuideTM and EMDOGAIN (R) applied (TE group). After 6-12 weeks of healing, histologic sections were processed and histologically analyzed. In new cementum of T, E, and TE groups, hardly any cement cells were recognized, and no significant differences in attachment pattern among the three groups were noticeable. More significant new bone formation was found in the TE group than in the other groups, suggesting that GTR with Tissue GuideTM and EMDOGAIN (R) applyied may facilitate periodontal tissue regeneration. J.
The purpose of this study is to evaluate the effects of Guided Tissue Regeneration (GTR) with biodegradable collagen membrane (Tissue GuideTM) and natural apatite composition materials (Bone Ject (R)) for experimental periodontal bone defect. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects measuring 5mm in width and 5mm in height were created. The experimental bone defects were treated by four different methods : (1) flap operation (control) , (2) GTR with biodegradable collagen membrane (T group) , (3) grafting Bone Ject (R) (B group) , (4) CI GTR with Tissue GuideTM and grafting Bone Ject (R) (TB group). After 24 and 48 weeks of healing, histologic sections were processed and histologically observed, showing that the TB group produced more new bone and new cementum than the other groups. When granules of Bone Ject (R) remained, the structure was observed smaller. Our study suggested that Bone Ject (R) reconstract a periodontal tissue while it is absorbed partially.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.