Different Cross‐Linked Types of Collagen Implanted in Rat Palatal Gingiva

Minabe, Masato; Kodama, Tatsuhiko; Kogou, Tatsuji; Tamura, Toshiyuki; Hori, Tomohide; Watanabe, Y.; Miyata, Teruo

doi:10.1902/jop.1989.60.1.35

Cited by 80 publications

(63 citation statements)

References 21 publications

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“…This means that the number of collagen crosslinks is proportional to both the stiffness of the membrane and the degradation time. 6,7 The most frequently used crosslinking method is to tan the collagen with glutaraldehyde (GA), which, although an effective cross-linking agent, has been shown in vitro 8 and in vivo 9 to increase the cytotoxicity of collagen membranes. GA is released during collagen degradation, and a constant release of remnant (non reacted) GA has been shown to inhibit cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review

et al. 2008

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Collagen barrier membranes are frequently used in both guided tissue regeneration (GTR) and guided bone regeneration (GBR). Collagen used for these devices is available from different species and is often processed to alter the properties of the final product. This is necessary because unprocessed collagen is rapidly resorbed in vivo and demands for barrier membranes are different in GTR and GBR. This systematic literature review attempts to evaluate possible effects of collagen origin and mode of cross-linking on the potential of different cells to attach to, proliferate on, and migrate over barrier membranes in vitro. Seventeen original studies, selected by a systematic process, are included in this review. The results show that fibroblasts of different species and originating tissues as well as bone-forming cells are able to attach to collagen membranes irrespective of collagen origin or mode of processing. Different cell types behave differently on identical membranes. Many pieces of evidence are currently available, and we attempted to elucidate the effects of collagen origin and mode of processing on cellular behavior, but further research will be required before it will be possible to predict for certain the effect a specific procedure will have with a given product.

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Section: Introductionmentioning

confidence: 99%

Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review

et al. 2008

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“…However, clinical application of SFM Silk membrane plus 3% 4-hexylresorcinol (3% 4-HR + SM), collagen membrane (CM). In an in vitro study of rat palatal gingiva, migration and downgrowth of the epithelium occurred after 2 weeks of GBR Minabe et al 1989). Migration of bone and periodontal ligament cells to a bone defect reaches peak activity 2 to 7 days after initiating GBR and then decreases to almost normal levels 21 days later (Iglhaut et al 1988).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model

Seok¹,

Lee²,

Kim³

et al. 2013

International Journal of Industrial Entomology

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The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (μ-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by μ-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.

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“…Thus, the effectiveness of the collagen membrane was debated in regeneration literature because of its relatively fast resorption rate even after cross-linking. However, recently reported evidence suggested that since the epithelial proliferation occurs within the first 14 days of periodontal wound healing, it is postulated that the period of time in which a collagen membrane remains intact is sufficient to inhibit epithelial migration (19,21).…”

Section: Bioabsorbable Barrier Membranesmentioning

confidence: 99%

Barrier Membrane, a Device for Regeneration: Properties and Applications

Soheilifar¹,

Soheilifar²,

Bidgoli³

et al. 2014

Avicenna J Dent Res

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Context: This article reviews the available evidence about the barrier membranes utilized in Guided Tissue Regeneration process to prevent the migration of unfavorable cells to the wound area. Evidence Acquisition: Available evidence about membranes properties and their different uses were reviewed, and the results of clinical and animal studies and systematic reviews were gathered. Results: A large number of existing membranes with different features and compositions may lead to different study results; none of the available membranes can result in %100 predictable outcomes. Conclusions: Effectiveness of membranes in treating intrabony defects is very controversial; however, treating furcation defects using membranes was reported to be successful in a large number of studies.

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Different Cross‐Linked Types of Collagen Implanted in Rat Palatal Gingiva

Cited by 80 publications

References 21 publications

Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review

Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review

The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model

Barrier Membrane, a Device for Regeneration: Properties and Applications

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