The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model

Seok, Hyun‐Kwang; Lee, Sang Woon; Kim, Seong‐Gon; Seo, Dong Han; Kim, Han Sung; Kweon, HaeYong; Jo, You Young; Kang, Taejoon; Lee, Myung Jin; Chae, Weon‐Sik

doi:10.7852/ijie.2013.27.1.209

Cited by 8 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, 4-hexylresorcinol has been shown to inhibit the pathways of nuclear factor-κB (NF-κB) [119], a molecule involved in osteoclast differentiation, with a resorptive role. Favorable results have been obtained in vivo and in other studies [120,121]. One of the obstacles to the practical applicability of these membranes is represented by their poor mechanical properties [45].…”

Section: Membranes With Antimicrobial Factorsmentioning

confidence: 99%

Finding the Perfect Membrane: Current Knowledge on Barrier Membranes in Regenerative Procedures: A Descriptive Review

et al. 2022

View full text Add to dashboard Cite

Guided tissue regeneration (GTR) and guided bone regeneration (GBR) became common procedures in the corrective phase of periodontal treatment. In order to obtain good quality tissue neo-formation, most techniques require the use of a membrane that will act as a barrier, having as a main purpose the blocking of cell invasion from the gingival epithelium and connective tissue into the newly formed bone structure. Different techniques and materials have been developed, aiming to obtain the perfect barrier membrane. The membranes can be divided according to the biodegradability of the base material into absorbable membranes and non-absorbable membranes. The use of absorbable membranes is extremely widespread due to their advantages, but in clinical situations of significant tissue loss, the use of non-absorbable membranes is often still preferred. This descriptive review presents a synthesis of the types of barrier membranes available and their characteristics, as well as future trends in the development of barrier membranes along with some allergological aspects of membrane use.

show abstract

Section: Membranes With Antimicrobial Factorsmentioning

confidence: 99%

Finding the Perfect Membrane: Current Knowledge on Barrier Membranes in Regenerative Procedures: A Descriptive Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…4-HR is a component of silk-based membranes for the GBR technique, and it shows higher bone regeneration ability in bone defects [72]. 4-HR-incorporated silk membranes are used in the calvarial defect, and they show more new bone regeneration compared with silk-only membranes [73], and the 3% 4-HR-loaded silk membrane showed more new bone formation compared with the commercial collagen membrane in the rabbit calvarial defect (Figure 4) [72,74]. In peri-implant defects, 4-HR stably maintains the space for new bone growth and effectively induces new bone regeneration around the implant ( Figure 5) [18].…”

Section: -Hexylresorcinolmentioning

confidence: 99%

Silk Protein-Based Membrane for Guided Bone Regeneration

Kwon

Seok

2018

Applied Sciences

Self Cite

View full text Add to dashboard Cite

Silk derived from the silkworm is known for its excellent biological and mechanical properties. It has been used in various fields as a biomaterial, especially in bone tissue engineering scaffolding. Recently, silk protein-based biomaterial has been used as a barrier membrane scaffolding for guided bone regeneration (GBR). GBR promotes bone regeneration in bone defect areas using special barrier membranes. GBR membranes should have biocompatibility, biodegradability, cell occlusion, the mechanical properties of space-making, and easy clinical handling. Silk-based biomaterial has excellent biologic and mechanical properties that make it a good candidate to be used as GBR membranes. Recently, various forms of silk protein-based membranes have been introduced, demonstrating excellent bone regeneration ability, including osteogenic cell proliferation and osteogenic gene expression, and promoting new bone regeneration in vivo. In this article, we introduced the characteristics of silk protein as bone tissue engineering scaffolding and the recent application of such silk material as a GBR membrane. We also suggested future studies exploring additional uses of silk-based materials as GBR membranes.

show abstract

“…It is widely used in medical application such as orthopedics and dentistry. However, it has limited use in load bearing applications due to its low strength and brittle [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%