This clinical study evaluated the effectiveness of guided tissue regeneration using a resorbable collagen membrane and bone swaging in noncontained infrabony defects by assessing changes in probing pocket depth, probing attachment level, and radiographic bone level after 6 months, 1 year, and 2 years. Postsurgical clinical and radiographic measurements were statistically significantly different from presurgical measurements. The rate of bone fill was positively associated with the baseline depth of the bone defect but not associated with the width. The noncontained infrabony defects treated with this combined regenerative method improved clinically and radiographically.
The purpose of this study is to evaluate the effects of Guided Tissue Regeneration (GTR) with biodegradable collagen membrane (Tissue GuideTM) and natural apatite composition materials (Bone Ject (R)) for experimental periodontal bone defect. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects measuring 5mm in width and 5mm in height were created. The experimental bone defects were treated by four different methods : (1) flap operation (control) , (2) GTR with biodegradable collagen membrane (T group) , (3) grafting Bone Ject (R) (B group) , (4) CI GTR with Tissue GuideTM and grafting Bone Ject (R) (TB group). After 24 and 48 weeks of healing, histologic sections were processed and histologically observed, showing that the TB group produced more new bone and new cementum than the other groups. When granules of Bone Ject (R) remained, the structure was observed smaller. Our study suggested that Bone Ject (R) reconstract a periodontal tissue while it is absorbed partially.
The purpose of this study is to reconsider the attachment pattern and to evaluate the effects of Guided Tissue Regeneration (GTR) with Biodegradable collagen membrane (Tissue GuideTM) and enamel matrix protein (EMDOGAIN (R)) applied to experimental periodontal bone defects. The mesial roots of the lower third and fourth premolars from 10 beagle dogs were used. Mucoperiosteal flaps were reflected and bone defects were created measuring 5 mm in width and 5 mm in height. The experimental bone defects were treated by four different methods: (1) flap operation (control) ; (2) GTR with biodegradable collagen membrane (Tissue GuideTM) (T group) ; (3) applying enamel matrix protein (EMDOGAIN (R)) (E group) ; (4) GTR with Tissue GuideTM and EMDOGAIN (R) applied (TE group). After 6-12 weeks of healing, histologic sections were processed and histologically analyzed. In new cementum of T, E, and TE groups, hardly any cement cells were recognized, and no significant differences in attachment pattern among the three groups were noticeable. More significant new bone formation was found in the TE group than in the other groups, suggesting that GTR with Tissue GuideTM and EMDOGAIN (R) applyied may facilitate periodontal tissue regeneration. J.
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