Little is known about the clinicopathologic char− acteristics of primary follicular lymphoma of the gastrointestinal tract (PFLGI). We report our ex− perience with double−balloon enteroscopy (DBE) in patients with PFLGI. Between January 2001 and December 2006, thirteen patients with PFLGI (nine men and four women; mean age, 53.4 years) visited Hiroshima University Hospital. We performed DBE in 11 PFLGI patients to examine the entire small bowel. DBE showed new lesions in the third portion of the duodenum, jejunum, or ileum in nine of these 11 patients (81.8 %). The en− doscopic finding was nodularity of the involved mucosal surface (small whitish polyps or whitish granules). Seven patients were treated with ri− tuximab plus CHOP chemotherapy (R−CHOP). A complete response was obtained in all patients who received R−CHOP, and no recurrence was seen (mean follow−up period, 22.5 months).

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Direct spraying of TJ-68 on the colonic mucosa suppressed colonic spasm and it may be useful during colonoscopy when anticholinergic agents are contraindicated.

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The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC.

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