at the 44th Annual Meeting of the Japanese Smooth Muscle Society

Nakada, Koji; Aoyama, Nobuo; Nakagawa, Manabu; Kawasaki, Norihito; Shirasaka, Daisuke; Zai, Hiroaki; Urita, Yoshihisa; Kitagawa, Yasushi; Koyama, Shigeki; Shishido, Tadayuki; Kusunoki, Hiroaki; Kato, Mototsugu; Hanyu, Nobuyoshi; Haruma, Ken; Hongo, Michio

doi:10.1540/heikatsukinzashi1997.6.j75

Cited by 17 publications

(14 citation statements)

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“…In scintigraphic measurements, the lag phase is arbitrarily defined as the initial post-meal period during which only a small portion of food (5%-10%) leaves the stomach (Mariani et al, 2004). In breath testing, on the other hand, more than 80% of the gastric content leaves the stomach by the time at which the [ 13 CO2] excretion rate is maximized, namely Tlag (Nakada et al, 2002). In this sense, a view that Tlag corresponds to the lag phase is unreasonable (Kitagawa et al, 2002;Zai et al, 2002).…”

Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

“…In breath testing, on the other hand, more than 80% of the gastric content leaves the stomach by the time at which the [ 13 CO2] excretion rate is maximized, namely Tlag (Nakada et al, 2002). In this sense, a view that Tlag corresponds to the lag phase is unreasonable (Kitagawa et al, 2002;Zai et al, 2002). At present, we think it more pragmatic to consider that what the parameters indicate is merely whether gastric emptying is rapid, normal, or slow.…”

Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

“…However, the novel analytical strategies have not been widely endorsed yet. Several authors uphold an opinion that the terms of "the half-emptying time" (T1/2b) and "the lag phase" (Tlag) are used equivocally (Schommartz et al, 1998;Nakada et al, 2002). The two terms were originally applied to characterize a real pattern of gastric emptying, which is "directly" assessed by the intubation technique or the scintigraphy.…”

Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

“…The ambiguity has led to a longstanding debate. Last of all, since a myriad of protocols have been proposed, breath-test users are bothered in determining which to select (Nakada et al, 2002). Development of a standard protocol is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Sanaka

Nakada

2010

J. Smooth Muscle Res.

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A stable isotope ([ 13 C]) breath test is a promising method for assessing gastric emptying, but it has not been pervasive yet in Japan. We think that there are some barriers to its popularization, including the uncertainty concerning its theoretical backgrounds, the ambiguity of analyzing and interpreting the data, and the lack of standard protocols for breath sampling. The aim of the present review is to break through these barriers. We hope this article could make the [ 13 C]-gastric breath test more maneuverable for and more accessible to researchers and clinicians.

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Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

Section: Interpretation Of Breath-test Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Sanaka

Nakada

2010

J. Smooth Muscle Res.

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“…In contrast to the results of Ghoos et al (1993), Choi et al (1997) and demonstrated a much weaker correlation between T1/2b and T1/2s. Nakada et al (2002) and Shirasaka et al (2002) seem to hold the view that T1/2b has no advantage over Tmax in the gastric emptying breath test.…”

Section: Introductionmentioning

confidence: 98%

Reliability of the time to maximal [13CO2] excretion and the half-[13CO 2] excretion time as a gastric emptying parameter: Assessments using the Wagner-Nelson method

Sanaka

Yamamoto

Nakayama

et al. 2007

J. Smooth Muscle Res.

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In the [ 13 C]-octanoate breath test, two popular parameters have been used to quantify gastric emptying rates, namely the time to the maximal [ 13 CO2] excretion (Tmax) and the time to the half-[ 13 CO2] recovery (T1/2b). Although each of Tmax and T1/2b is closely correlated with the scintigraphic half-emptying time, the two parameters occasionally indicate different judgments on a gastric emptying rate. In this study, to clarify which of the two parameters is more reliable, Tmax and T1/2b were compared to the "reference" parameters calculated using the Wagner-Nelson method, which allows accurate estimation of a time-course of gastric emptying from breath data. Ten healthy male volunteers underwent the breath test after ingestion of a muffin meal (320 kcal) containing 100 mg [ 13 C]-octanoate. Breath samples were collected at 15-min intervals for 6 h. According to the conventional analytical algorithm, Tmax and T1/2b were mathematically calculated. By applying Wagner-Nelson analysis to the breath test, the time-percent gastric retention curve was generated and the half-emptying time (T1/2WN) was determined. T1/2WN was more closely correlated with Tmax (r=0.954, P<0.0001) than with T1/2b (r=0.782, P=0.008). Tmax was significantly correlated with the percent gastric retention value in the early (t=0.25 and 0.5 h), the middle (t=1.0 and 1.5 h), and the late (t=2.0 h) postprandial phase. T1/2b was significantly correlated with the gastric retention value in the middle and the late phase, but not with the gastric retention value in the early phase. The present results show that T1/2b has limited capability to reflect gastric emptying in the early postprandial period, suggesting that Tmax is more reliable than T1/2b as a gastric emptying parameter.

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Serum high‐molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus

Iwase

Iino

Oku

et al. 2009

Diabetes Metabolism Res

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at the 44th Annual Meeting of the Japanese Smooth Muscle Society

Cited by 17 publications

References 0 publications

Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Reliability of the time to maximal [<sup>13</sup>CO<sub>2</sub>] excretion and the half-[<sup>13</sup>CO <sub>2</sub>] excretion time as a gastric emptying parameter: Assessments using the Wagner-Nelson method

Serum high‐molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus

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