Serum high‐molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus

Iwase, Masanori; Iino, Kozo; Oku, Miwako; Nohara, Satoshi; Asano, Tomonari; Doi, Yasufumi; Iida, Mitsuo

doi:10.1002/dmrr.954

Cited by 6 publications

(8 citation statements)

References 47 publications

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“…Given the assumption that HM composition potentially influences GE [ 14 , 71 ], in term infants we expected the appetite hormones to be associated with infant GE rate such that high concentrations and/or doses of leptin would result in slower GE [ 30 ], whereas adiponectin might induce faster GE [ 37 ] consistent with both animal and human models. However, neither the concentrations nor doses of these hormones were related to GE rate.…”

Section: Discussionmentioning

confidence: 99%

“…In the animal model adiponectin inhibits tension-sensitive gastric vagal afferent mechanosensitivity, modulating satiety signals in both lean and obese animals, while simultaneously increasing the mechanosensitivity of mucosal gastric vagal afferent in the obesity-induced model [ 36 ]. In humans, elevated serum levels of adiponectin are associated with more rapid GE in diabetic patients [ 37 ]. It is not known whether adiponectin levels impact GE in the infant and this warrants further investigation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Human Milk Appetite Hormones, Macronutrients, and Infant Characteristics on Gastric Emptying and Breastfeeding Patterns of Term Fully Breastfed Infants

et al. 2016

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Human milk (HM) components influence infant feeding patterns and nutrient intake, yet it is unclear how they influence gastric emptying (GE), a key component of appetite regulation. This study analyzed GE of a single breastfeed, HM appetite hormones/macronutrients and demographics/anthropometrics/body composition of term fully breastfed infants (n = 41, 2 and/or 5 mo). Stomach volumes (SV) were calculated from pre-/post-feed ultrasound scans, then repeatedly until the next feed. Feed volume (FV) was measured by the test-weigh method. HM samples were analyzed for adiponectin, leptin, fat, lactose, total carbohydrate, lysozyme, and total/whey/casein protein. Linear regression/mixed effect models were used to determine associations between GE/feed variables and HM components/infant anthropometrics/adiposity. Higher FVs were associated with faster (−0.07 [−0.10, −0.03], p < 0.001) GE rate, higher post-feed SVs (0.82 [0.53, 1.12], p < 0.001), and longer GE times (0.24 [0.03, 0.46], p = 0.033). Higher whey protein concentration was associated with higher post-feed SVs (4.99 [0.84, 9.13], p = 0.023). Longer GE time was associated with higher adiponectin concentration (2.29 [0.92, 3.66], p = 0.002) and dose (0.02 [0.01, 0.03], p = 0.005), and lower casein:whey ratio (−65.89 [−107.13, −2.66], p = 0.003). FV and HM composition influence GE and breastfeeding patterns in term breastfed infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Human Milk Appetite Hormones, Macronutrients, and Infant Characteristics on Gastric Emptying and Breastfeeding Patterns of Term Fully Breastfed Infants

et al. 2016

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“…In another study investigating the role of adiponectin in the early rise in the postprandial glycemic response, Iwase et al . showed that delayed gastric emptying was associated with lower high-molecular weight (HMW) adiponectin, but not total adiponectin [ 35 ]. Although HMW adiponectin was not measured in the present study, further studies with a HMW adiponectin assay may help to clarify the pathophysiology of GERD.…”

Section: Discussionmentioning

confidence: 99%

Associations of Circulating Gut Hormone and Adipocytokine Levels with the Spectrum of Gastroesophageal Reflux Disease

et al. 2015

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ObjectiveThe pathogenesis of gastroesophageal reflux disease (GERD) is complex and poorly understood. We aim to investigate the association of various circulating peptide hormones with heterogenous manifestations of GERD.MethodsOne hundred and four patients that had experienced typical GERD symptoms (heartburn and/or acid regurgitation) for at least 3 episodes per week in the past 3 months were enrolled. All patients received a baseline assessment of symptom severity and frequency with the Reflux Disease Questionnaire and an upper endoscopy to classify GERD into erosive esophagitis (EE, n = 67), non-erosive esophagitis (NE, n = 37), and Barrett’s esophagus (BE, n = 8). Fifty asymptomatic subjects with an endoscopically normal esophagus were recruited as the control group. Complete anthropometric measures and blood biochemistry were obtained and fasting serum levels of adipocytokines (adiponectin and leptin) and gut hormones (ghrelin and peptide YY (PYY)) were determined by enzyme-linked immunosorbent assay in all subjects.ResultsAll circulating peptide hormone levels were not statistically different between the GERD and control groups. However, GERD patients appeared to have lower PYY levels [median (25th-75th percentile), 80.1 (49.8–108.3) vs. 99.4 (65.8–131.9) pg/ml, p = 0.057] compared with control subjects. Among the GERD patients, ghrelin levels were inversely associated with the frequency and severity of acid regurgitation. In male GERD patients, EE was associated with significantly higher PYY levels [107.0 (55.0–120.8) vs. 32.8 (28.7–84.5) pg/ml, p = 0.026] but lower adiponectin levels [6.7 (5.6–9.3) vs. 9.9 (9.6–10.6) μg/ml, p = 0.034] than NE. Patients with BE had significantly lower adiponectin levels [6.0 (5.1–9.2) vs. 9.2 (7.1–11.2) μg/ml, p = 0.026] than those without BE.ConclusionsHumoral derangement of circulating peptide hormones might participate in inflammation and symptom perception in patients suffering from GERD. Further studies to clarify the exact role of these hormones in the pathogenesis of GERD are warranted.

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“…Adiponectin in human serum forms a wide range of multimers from trimers and hexamers (low and/or medium molecular weight, LMW/MMW) to high molecular weight (HMW) dodecamers and 18 mers. Almost all adiponectin in plasma appears to exist as full-length adiponectin molecule 59–61. Recent research has indicated that HMW adiponectin has bioactivity.…”

Section: Plasma Protein Levels and Disease Relationships For Adiponectinmentioning

confidence: 99%

“…Recent research has indicated that HMW adiponectin has bioactivity. Serum HMW adiponectin is related to early postprandial glycemic increases and gastric emptying in T2D patients 61,62. However, a comparative evaluation study with the limited number of subjects (n = 60) does not support the superiority of HMW over total adiponectin in assessing metabolic variables at baseline or in response to physical training 63.…”

Section: Plasma Protein Levels and Disease Relationships For Adiponectinmentioning

confidence: 99%

Biomarkers of Adiponectin: Plasma Protein Variation and Genomic DNA Polymorphisms

2009

Biomark�Insights

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Adiponectin is secreted by white adipose tissue and exists as the most abundant adipokine in the human plasma. Recent research has indicated that plasma adiponectin levels are inversely correlated with body mass index (BMI) and insulin resistance. Reduction of plasma adiponectin levels is commonly observed in the patients with type 2 diabetes (T2D) and/or in those who are obese in comparison with healthy control individuals. The adiponectin (AdipoQ) gene has a moderate linkage disequilibrium (LD), but two small LD blocks are observed, respectively, in the promoter region and the boundary of exon 2-intron 2. Genetic association studies have demonstrated that single nucleotide polymorphisms (SNPs) +45G15G(T/G) in exon 2 and +276G/T in intron 2 of the AdipoQ gene confer the risk susceptibility to the development of T2D, obesity and diabetic nephropathy (DN). The SNPs in the promoter region, including −11426A/G, −11377C/G and −11391G/A, are found to be associated with T2D and DN. Recent research has indicated that the promoter polymorphisms interfere with the AdipoQ promoter activity. The haplotypes constructed by the promoter polymorphisms and SNP +276G/T in intron 2 are associated with circulating adiponectin levels. This review summarises genetic and pathophysiological relevancies of adiponectin and discusses about the biomarkers of adiponectin plasma protein variation and genomic DNA polymorphisms.

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Serum high‐molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus

Abstract: Early postprandial glycemic increases were related to elevated serum high-molecular weight adiponectin, which might be associated with enhanced gastric emptying.

Cited by 6 publications

References 47 publications

Effect of Human Milk Appetite Hormones, Macronutrients, and Infant Characteristics on Gastric Emptying and Breastfeeding Patterns of Term Fully Breastfed Infants

Effect of Human Milk Appetite Hormones, Macronutrients, and Infant Characteristics on Gastric Emptying and Breastfeeding Patterns of Term Fully Breastfed Infants

Associations of Circulating Gut Hormone and Adipocytokine Levels with the Spectrum of Gastroesophageal Reflux Disease

Biomarkers of Adiponectin: Plasma Protein Variation and Genomic DNA Polymorphisms

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