Objective assessment of the antispasmodic effect of Shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy

Ai, Masato; Yamaguchi, Taketo; Odaka, Takeo; Mitsuhashi, Kanae; Shishido, Tadayuki; Yan, Jiaqin; Seza, Ayaka; Saisho, Hiromitsu

doi:10.3748/wjg.v12.i5.760

Cited by 24 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These two herbs has been shown to suppress the neurogenic contractions of the ileum induced by electrical stimulation and ganglionicstimulating agents in guinea pigs via inhibition of acetylcholine (Ach) release from cholinergic nerves and inhibition of Ach action on ileum smooth muscle (Maeda et al, 1983). Likewise, their antispasmodic effect on the human colon has been confirmed (Ai et al, 2006).…”

Section: Clinical Application and Pharmacology Of Kenchuto-based Jhmsmentioning

confidence: 94%

Constipation and Herbal Medicine

Iizuka¹

2016

Herbal Medicines

View full text Add to dashboard Cite

Citation:Iizuka N and Hamamoto Y (2015) Constipation and herbal medicine.Front. Pharmacol. 6:73. doi: 10.3389/fphar.2015.00073 Constipation is characterized by a variety of bowel symptoms such as difficulty passing stool, hard stool, and a feeling of incomplete evacuation. The multifactorial causes of constipation limit the clinical efficacy of current conventional treatments that use a single drug that acts through only one pathway. To complement the shortcomings of the current Western medical model and provide a complete holistic approach, herbal medicines capable of targeting multiple organs and cellular sites may be used. In Japan, many herbs and herbal combinations have traditionally been used as foods and medicines. Currently, Japanese physicians use standardized herbal combinations that provide consistent and essential quality and quantity. This review highlights representative Japanese herbal medicines (JHMs), Rhei rhizoma-based JHMs including Daiokanzoto and Mashiningan, and Kenchuto-based JHMs including Keishikashakuyakuto and Daikenchuto, which coordinate the motility of the alimentary tract. This review provides a framework to better understand the clinical and pharmacological efficacies of JHMs on constipation according to the unique theory of Japanese traditional medicine, known as Kampo medicine. Constipation and herbal medicine

show abstract

Section: Clinical Application and Pharmacology Of Kenchuto-based Jhmsmentioning

confidence: 94%

Constipation and Herbal Medicine

Iizuka¹

2016

Herbal Medicines

View full text Add to dashboard Cite

show abstract

“…About twenty seconds later, they documented a relaxation of the musculature that lasted about twenty minutes. Finally, Ai et al [48] evaluated the antispasmodic effect of the Chinese herbal medicine Shakuyaku-kanzoto (TJ-68) on the colonic wall by direct spraying during colonoscopy. TJ-68 is an extract powder composed of Shakuyaku (Paeoniae radix) and Kanzo (Glycyrrhizae radix) combined at a ratio of 1:1, and inhibits acetylcholineinduced contraction and the contractile machinery of the smooth muscle.…”

Section: New Endoscopic Technologies For Colon Examinationmentioning

confidence: 99%

Colonoscopy, pain and fears: Is it an indissoluble trinomial?

Trevisani

Zelante

Sartori

2014

WJGE

View full text Add to dashboard Cite

Colonoscopy is the reference method in the secondary prevention, diagnosis and, in some cases, treatment of colorectal cancer. It can often cause pain associated with embarrassment, anxiety, and physical and emotional discomfort. Pain intensity is influenced by a lot of factors, and there is a strict relationship among pain, pain perception, and mind. Several methods can be used to break the trinomial colonoscopy, pain and fear. Sedoanalgesia is recommended by several guidelines. If no sedation is offered, the patient must accept a higher chance of unacceptable discomfort and the endoscopist a lower chance of completing the procedure because of patient discomfort. Other non-pharmacologic methods such as acupuncture, music, and hydrocolonoscopy can be used as alternatives to pharmacologic sedoanalgesia. Furthermore, new endoscopic technologies such as variable-stiffness colonoscopes and ultrathin colonoscopes, or the use of carbon dioxide instead of air for colon insufflation, can reduce the pain caused by colonoscopy. In the future, technical improvements such as wireless capsules or robotic probes, will probably enable to overcome the present concept of colonoscopy, avoiding the use of traditional endoscopes. However, at present the poor attention paid by endoscopists to the pain and discomfort caused by colonoscopy can not be justified. There are several methods to reduce pain and anxiety and to break the trinomial colonoscopy, pain and fear. We must use them.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Colonoscopy; Pain; Fear; Anxiety; Discomfort; Conscious sedation Core tip: Colonoscopy can often cause pain associated with embarrassment, anxiety, and physical and emotional discomfort. Control of discomfort and pain during colonoscopy is considered to be a high priority by patients. This review of the literature encompasses the main methods for reducing pain and anxiety, to break the trinomial colonoscopy, pain and fear.

show abstract

“…Intramuscular or intravenous administration of an anti-cholinergic agent such as hyoscine- N -butyl bromide is generally required to abolish peristalsis [14]. Administration of an anti-cholinergic drug may, however, cause potentially serious complications, including cardiovascular events, urinary retention and ocular hypertension [4]. Glucagon may also be used to reduce peristalsis, but while it has fewer adverse effects on the cardiovascular system, it may induce hyperglycaemia [15].…”

Section: Discussionmentioning

confidence: 99%

“…Anti-spasmodics such as hyoscine- N -butylbromide or glucagon are often used to inhibit duodenal spasm [2], but their systemic use may cause adverse events, including dry mouth, urinary retention, orthostatic hypotension, palpitations, hyperglycaemia and anaphylaxis. Furthermore, these drugs are contraindicated in participants with ischaemic heart disease, prostatic hypertrophy, glaucoma and diabetes mellitus [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

The influence of duodenally-delivered Shakuyakukanzoto (Shao Yao Gan Cao Tang) on duodenal peristalsis during endoscopic retrograde cholangiopancreatography: a randomised controlled trial

et al. 2017

View full text Add to dashboard Cite

BackgroundAnti-cholinergic agents may be used to inhibit duodenal peristalsis, but they may have adverse effects. Shakuyakukanzoto (Shao Yao Gan Cao Tang) has an anti-spasmodic effect and has been used before for oesophagogastroduodenoscopy and colonoscopy. This randomised clinical trial aimed to evaluate the inhibitory effect of Shakuyakukanzoto on duodenal peristalsis, and its usefulness when administered into the duodenum just before endoscopic retrograde cholangiopancreatography (ERCP).MethodsParticipants were recruited between June 2008 and December 2010. All were aged ≥18 years and provided written informed consent. Exclusion criteria were: acute pancreatitis, a history of ischemic heart disease, prostatic hypertrophy or glaucoma, and altered/postsurgical upper gastrointestinal anatomy. The recruited participants were randomly assigned to the Shakuyakukanzoto group and control group. Shakuyakukanzoto 100 mg/mL solution or placebo (warm water) was administered directly as a spray into the duodenum during endoscopy. Efficacy was evaluated by observing the extent of duodenal peristalsis and assessing the difficulty of cannulating the common bile duct, the required time (RT) from administration to inhibition of duodenal peristalsis and the stop duration time (DT, the duration for which peristalsis was inhibited). Side effects were evaluated by measuring serum potassium concentration after ERCP.ResultsOf 28 participants, 15 were assigned to the Shakuyakukanzoto group and 13 to the control group. Duodenal peristalsis was inhibited in eight of the 10 eligible participants (80.0%) in the Shakuyakukanzoto group and none (0%) of the nine eligible participants in the control group (P = 0.026). In the Shakuyakukanzoto group, mean RT (±standard deviation) was 76.0 ± 23.9 s and DT was 11.3 ± 4.2 min. No adverse effects were observed in the Shakuyakukanzoto group during or after ERCP.ConclusionDuodenal peristalsis can be inhibited by spraying Shakuyakukanzoto solution directly into the duodenum. Trial registration UMIN Clinical Trials Registry (UMIN-CTR) UMIN000011469Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0125-6) contains supplementary material, which is available to authorized users.

show abstract

Objective assessment of the antispasmodic effect of Shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy

Abstract: Direct spraying of TJ-68 on the colonic mucosa suppressed colonic spasm and it may be useful during colonoscopy when anticholinergic agents are contraindicated.

Cited by 24 publications

References 13 publications

Constipation and Herbal Medicine

Constipation and Herbal Medicine

Colonoscopy, pain and fears: Is it an indissoluble trinomial?

The influence of duodenally-delivered Shakuyakukanzoto (Shao Yao Gan Cao Tang) on duodenal peristalsis during endoscopic retrograde cholangiopancreatography: a randomised controlled trial

Contact Info

Product

Resources

About