Assessment of various indexs for gastric emptying study by &lt;SUP&gt;13&lt;/SUP&gt;C-octanoic acid breath test-with special reference to T&lt;SUB&gt;max&lt;/SUB&gt;

Shishido, Tadayuki; Yamaguchi, Taketo; Odaka, Takeo; Ai, Masato; Mitsuhashi, Kanae; Yamaguchi, Kazuya; Shinpo, Izumi; Koma, Yosihiro; Saisho, Hiromitsu

doi:10.1540/heikatsukinzashi1997.6.j149

Cited by 3 publications

(4 citation statements)

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“…This finding is quite understandable, considering that the CPDR[t] curve changes minimally while the PDR[t] curve does dynamically in the early phase (Zai et al, 2009). Next, T1/2b would be prone to mistakenly judge a "normal" emptying to be "delayed" in case that the PDR[t] curve exhibits a very gentle descending slope Shishido et al, 2002;Lee et al, 2000;Sanaka et al, 2007b); in such a case, we speculates that the retention, rather than a real delay in the emptying, makes the pulmonary […”

Section: And the Cpr [T] Curve (The Velocity) Is Flattened Without A mentioning

confidence: 99%

“…It is reasonable to consider that a high statistical correlation between Tmax and T1/2b reported (Schommartz et al, 1998;van Nieuwenhoven et al, 1999;Shishido et al, 2002) justifies the mutual exchange of the two parameters, either of which could be rejected according to researchers' preferences. Generally, T1/2b seems more popular than Tmax, despite a lack of tangible supportive evidence (Sanaka et al, 2007b).…”

Section: And the Cpr [T] Curve (The Velocity) Is Flattened Without A mentioning

confidence: 99%

“…The accuracy of Tmax would be equivalent either based on the curve-fitting or based on the visual inspection, if only breath samples are collected frequently (Braden et al, 1995;Nakada et al, 2002). In addition, the test duration could effectively be shortened using the visually determined Tmax, because most of the descending phase of the plot is unnecessary for the determination (Nakada et al, 2002;Shishido et al, 2002). There seems no particular reason for use of the model-dependent Tmax over the more convenient, model-independent one.…”

Section: Sampling Frequency and Durationmentioning

confidence: 99%

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Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Sanaka

Nakada

2010

J. Smooth Muscle Res.

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A stable isotope ([ 13 C]) breath test is a promising method for assessing gastric emptying, but it has not been pervasive yet in Japan. We think that there are some barriers to its popularization, including the uncertainty concerning its theoretical backgrounds, the ambiguity of analyzing and interpreting the data, and the lack of standard protocols for breath sampling. The aim of the present review is to break through these barriers. We hope this article could make the [ 13 C]-gastric breath test more maneuverable for and more accessible to researchers and clinicians.

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Section: And the Cpr [T] Curve (The Velocity) Is Flattened Without A mentioning

confidence: 99%

Section: And the Cpr [T] Curve (The Velocity) Is Flattened Without A mentioning

confidence: 99%

Section: Sampling Frequency and Durationmentioning

confidence: 99%

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Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Sanaka

Nakada

2010

J. Smooth Muscle Res.

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“…3). Shishido et al (2002) reported that Tmax and T1/2b often provided a different judgment on gastric emptying rate and in that case, a combination of normal Tmax and delayed T1/2b was much more frequent than a combination of delayed Tmax and normal T1/2b. The observation suggests that T1/2b is likely to judge gastric emptying to be delayed whether gastric emptying is really delayed or not.…”

Section: Discussionmentioning

confidence: 99%

Reliability of the time to maximal [13CO2] excretion and the half-[13CO 2] excretion time as a gastric emptying parameter: Assessments using the Wagner-Nelson method

Sanaka

Yamamoto

Nakayama

et al. 2007

J. Smooth Muscle Res.

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In the [ 13 C]-octanoate breath test, two popular parameters have been used to quantify gastric emptying rates, namely the time to the maximal [ 13 CO2] excretion (Tmax) and the time to the half-[ 13 CO2] recovery (T1/2b). Although each of Tmax and T1/2b is closely correlated with the scintigraphic half-emptying time, the two parameters occasionally indicate different judgments on a gastric emptying rate. In this study, to clarify which of the two parameters is more reliable, Tmax and T1/2b were compared to the "reference" parameters calculated using the Wagner-Nelson method, which allows accurate estimation of a time-course of gastric emptying from breath data. Ten healthy male volunteers underwent the breath test after ingestion of a muffin meal (320 kcal) containing 100 mg [ 13 C]-octanoate. Breath samples were collected at 15-min intervals for 6 h. According to the conventional analytical algorithm, Tmax and T1/2b were mathematically calculated. By applying Wagner-Nelson analysis to the breath test, the time-percent gastric retention curve was generated and the half-emptying time (T1/2WN) was determined. T1/2WN was more closely correlated with Tmax (r=0.954, P<0.0001) than with T1/2b (r=0.782, P=0.008). Tmax was significantly correlated with the percent gastric retention value in the early (t=0.25 and 0.5 h), the middle (t=1.0 and 1.5 h), and the late (t=2.0 h) postprandial phase. T1/2b was significantly correlated with the gastric retention value in the middle and the late phase, but not with the gastric retention value in the early phase. The present results show that T1/2b has limited capability to reflect gastric emptying in the early postprandial period, suggesting that Tmax is more reliable than T1/2b as a gastric emptying parameter.

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Autonomic dysfunction of gastric motility in major depression

Kheder

Heller

Bar

et al. 2018

Journal of Affective Disorders

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Assessment of various indexs for gastric emptying study by <SUP>13</SUP>C-octanoic acid breath test-with special reference to T<SUB>max</SUB>

Cited by 3 publications

References 0 publications

Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Stable isotope breath tests for assessing gastric emptying: A comprehensive review

Reliability of the time to maximal [<sup>13</sup>CO<sub>2</sub>] excretion and the half-[<sup>13</sup>CO <sub>2</sub>] excretion time as a gastric emptying parameter: Assessments using the Wagner-Nelson method

Autonomic dysfunction of gastric motility in major depression

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