Autonomic dysfunction of gastric motility in major depression

Kheder, Safar; Heller, J.; Bar, Jair; Wutzler, Alexander; Menge, Bjoern A.; Juckel, Georg

doi:10.1016/j.jad.2017.09.049

Cited by 25 publications

(11 citation statements)

References 65 publications

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“…OSA leads to the dysregulation of many biological pathways, the most important of which is the deregulation of the autonomic nervous system [ 22 ]. Autonomic nervous system disorders are commonly seen in CNS diseases [ 24 – 26 ], and are considered as potential biomarkers for premotor PD [ 26 ]. In early case of AD patients, a loss of dendritic branching and a decrease in dendritic spines were shown in the suprachiasmatic nuclei, the supraoptic nuclei, and the paraventricular nuclei, which were considered to be related to the disability of autonomic functions [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, our previous study demonstrated that the canine model of chronic OSA displayed autonomic nerve hyperinnervation [ 23 ]. Autonomic nerve dysfunction is also a cardinal feature of AD, Parkinson’s disease (PD) and depression [ 24 – 26 ]. Nevertheless, it remains unclear whether the autonomic nervous system is involved in OSA-associated CNS disorders.…”

Section: Introductionmentioning

confidence: 99%

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Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Yang

Zhao

et al. 2019

Acta Pharmacol Sin

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Obstructive sleep apnea (OSA) is closely associated with central nervous system diseases and could lead to autonomic nerve dysfunction, which is often seen in neurodegenerative diseases. Previous studies have shown that metoprolol prevents several chronic OSA-induced cardiovascular diseases through inhibiting autonomic nerve hyperactivity. It remains unclear whether chronic OSA can lead to dendritic remodeling in the brain, and whether metoprolol affects the dendritic remodeling. In this study we investigated the effect of metoprolol on dendrite morphology in a canine model of chronic OSA, which was established in beagles through clamping and reopening the endotracheal tube for 4 h every other day for 12 weeks. OSA beagles were administered metoprolol (5 mg· kg −1 · d −1 ). The dendritic number, length, crossings and spine density of neurons in hippocampi and prefrontal cortices were assessed by Golgi staining. And the protein levels of hypoxia-inducible factor-1α (HIF-1α) and brain-derived neurotrophic factor (BDNF) were measured by Western blotting. We showed that chronic OSA successfully induced significant brain hypoxia evidenced by increased HIF-1α levels in CA1 region and dentate gyrus of hippocampi, as well as in prefrontal cortex. Furthermore, OSA led to markedly decreased dendrite number, length and intersections, spine loss as well as reduced BDNF levels. Administration of metoprolol effectively prevented the dendritic remodeling and spine loss induced by chronic OSA. In addition, administration of metoprolol reversed the decreased BDNF, which might be associated with the metoprolol-induced neuronal protection. In conclusion, metoprolol protects against neuronal dendritic remodeling in hippocampi and prefrontal cortices induced by chronic OSA in canine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Yang

Zhao

et al. 2019

Acta Pharmacol Sin

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“…Resveratrol Contributes to the Gut-Brain Axis by Regulating the Expression of GLP-1 Lately, the relationship between the gut and brain has emerged as a critical issue for treatment of neuronal disorders, such as depression and dementia, as well as gastrointestinal diseases, such as diarrhea and irritable bowel syndrome (Haj Kheder et al, 2018;Simren et al, 2018Simren et al, , 2019.…”

Section: Resveratrol and The Gut-brain Axismentioning

confidence: 99%

Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota

Chung

Jeong

Song

2020

Front. Aging Neurosci.

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Resveratrol is a natural polyphenol that has anti-aging and anti-inflammatory properties against stress condition. It is reported that resveratrol has beneficial functions in various metabolic and central nervous system (CNS) diseases, such as obesity, diabetes, depression, and dementia. Recently, many researchers have emphasized the connection between the brain and gut, called the gut–brain axis, for treating both CNS neuropathologies and gastrointestinal diseases. Based on previous findings, resveratrol is involved in glucagon-like peptide 1 (GLP-1) secreted by intestine L cells, the patterns of microbiome in the intestine, the 5-hydroxytryptamine (5-HT) level, and CNS inflammation. Here, we review recent evidences concerning the relevance and regulatory function of resveratrol in the gut–brain axis from various perspectives. Here, we highlight the necessity for further study on resveratrol's specific mechanism in the gut–brain axis. We present the potential of resveratrol as a natural therapeutic substance for treating both neuropathology and gastrointestinal dysfunction.

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“…Gastroparesis is associated with depression and decreased quality of life [8][9][10][11]. Gastroparesis is associated with obesity [71].…”

Section: Altered Gastroduodenal Voiding (Foregut Involvement): a Link With Herpetic Infections?mentioning

confidence: 99%

“…Depression has been associated with numerous gastroenterological pathologies: e.g. constipation [1][2][3], overweight [4][5][6][7], gastroparesis [8][9][10][11], Ulcerative Colitis (UC) or Crohn's Disease (CD) [12], Irritable Bowel Syndrome (IBS) [13,14] or periodontitis [15]. Some Volatile Organic Compounds (VOCs) have been associated with central nervous system disturbances in animals [16][17][18] as well as in human exposed to toxics [19].…”

Section: Introductionmentioning

confidence: 99%

Ambulatory Detection of Volatile Organic Compounds (VOCs) Associated with Depression

Donatini¹,

Blaye²

2020

J Clin Case Stu

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Volume 5 -Issue 2 consideration since they are suspected to favour gastroparesis [21][22][23][24] or periodontitis [25][26][27][28][29][30]. Cytomegalovirus has also been implicated in the occurrence of depression [31,32], obesity [33,34], or UC [35]. Material and MethodsThis is a descriptive retrospective epidemiological study. Data were collected during the normal course of routine gastroenterological consultations for Small Intestinal Bowel Overgrowth (SIBO), from January 15, 2020 until March 15, 2020. There was no hypothesis testing before data collection, no data collection beyond that which is part of routine clinical practice, no scheduled data analysis before the work has already been done. This retrospective analysis of Case Series cannot therefore be qualified as "research" and does not requires approval from ethics boards designed to protect humans involved in clinical research, according to the International Committee of Medical Journal Editors (ICMJE). Inclusion criteriaPatients consulting for SIBO and who underwent a breath test. Patients should provide with a full medical history, especially

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Autonomic dysfunction of gastric motility in major depression

Cited by 25 publications

References 65 publications

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota

Ambulatory Detection of Volatile Organic Compounds (VOCs) Associated with Depression

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