Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer

Abstract

The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC.

Intestinal and Gastric Permeability in Children With Eosinophilic Esophagitis and Reflux Esophagitis

“…Although the role of intestinal permeability has yet to be determined, increased permeability may lead to increased absorption and exposure to foreign antigens and an upregulated immune response that is not limited to the GI tract (11,14). Alternatively, increased intestinal permeability in GI-specific disorders, such as celiac and Crohn disease, may be a consequence of intestinal inflammation and damage (14,15,20). There is limited evidence to suggest whether this phenomenon is cause or effect.…”

“…The results of this study, however, would suggest that gastric permeability does not play a role in the pathogenesis or pathophysiology of either disorder. Gastric permeability traditionally has been correlated with diseases involving a compromised gastric mucosa-peptic ulcer disease and gastritis-and may not be associated with diseases associated with increased intestinal permeability (15,16).…”

“…One hypothesis suggests that there is a greater transfer and exposure to antigens that trigger an increased immune response (14). Gastric permeability has never been studied in patients with EoE, but has been shown to be increased in gastric disease-peptic ulcer disease, gastritis, gastric cancer-more so than esophageal disease or other autoimmune conditions (15,16).…”

Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens

“…[ 58 ] showed previously that in vitro biofilm formation by S. sanguinis was far more efficient in the presence of sucrose because sucrose is converted into extracellular glucan [ 62 ]. The near absence of sucrose in the blood of normal people [ 188 , 189 ] would be expected to preclude glucan formation on infected heart valves.…”

Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy

“…12,13 Dysfunction of the epithelial barrier is characteristic of many human diseases of the GI tract, including carcinogenesis. [14][15][16][17] Recent studies have shown that barrier function is compromised in H pylori-induced gastritis, [18][19][20] and precancerous gastric lesions in rats exhibit disappearance of apical tight junctions. However, although these lesions are frequently precancerous, the epithelial barrier function has rarely been investigated in IM patients because of the patchy nature.…”