Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy

Ji, Rui; Zuo, Xu; Yu, Tao; Gu, Xiaomeng; Li, Zhen; Zhou, Chengjun; Li, Yanqing

doi:10.1016/j.gie.2011.12.016

Cited by 27 publications

(16 citation statements)

References 40 publications

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“…The longer dialysis period of the La deposition formation group in our cases (Group A) suggests the involvement of disrupted intercellular junctions throughout the gastrointestinal tract. In addition mucosal barrier defects are reported in gastric intestinal metaplasia . There seemed to be a relevance between La deposition and mucosal barrier defects like intestinal metaplasia, or the many erosions in our cases and in other reports …”

Section: Discussionsupporting

confidence: 76%

Correlation of lanthanum dosage with lanthanum deposition in the gastroduodenal mucosa of dialysis patients

Hattori

Maeda

Nishida

et al. 2017

Pathology International

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Lanthanum (La) deposition has been observed in gastrointestinal mucosa of dialysis patients treated with La carbonate to treat hyperphosphatemia in the 6 years since its authorization in Japan. We investigated gastrointestinal biopsies from 112 dialysis patients, and found 15 cases of histiocytic aggregation with crystalloids and one case of duodenitis with histiocyte aggregation without crystalloids in the 30 patients treated with La carbonate. No histiocytic lesions were observed in the 82 patients without La carbonate administration. So far in total 70 cases of La deposition in the alimentary tract have been reported, including our 16 cases. Neither clinical nor histological findings other than histiocytic aggregation were specific in the patients with La deposition. We also compared the groups with and without La deposition, revealing that the daily and total doses of La carbonate showed statistically significant correlations with La deposition. However the causality with their histologic features, e.g. intestinal metaplasia and degree of inflammation, were inconclusive between the two groups. Although no critical symptoms have been reported, it is necessary to accumulate more cases to clarify the mechanism of La deposition, because dialysis patients must take phosphate buffers for a long period.

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Section: Discussionsupporting

confidence: 76%

Correlation of lanthanum dosage with lanthanum deposition in the gastroduodenal mucosa of dialysis patients

Hattori

Maeda

Nishida

et al. 2017

Pathology International

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“…Disruption of the mucosal barrier is associated with some primary gastric disorders [7] . Therefore, we analyzed the expression of all mucosal barrier-related genes.…”

Section: Resultsmentioning

confidence: 99%

Identification of Differentially-Expressed Genes in Intestinal Gastric Cancer by Microarray Analysis

Zang

Guo

Xing

et al. 2014

Genomics, Proteomics &Amp; Bioinformatics

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Gastric cancer (GC) is one of the most frequent malignant tumors. In order to systematically characterize the cellular and molecular mechanisms of intestinal GC development, in this study, we used 22 K oligonucleotide microarrays and bioinformatics analysis to evaluate the gene expression profiles of GC in 45 tissue samples, including 20 intestinal GC tissue samples, 20 normal appearing tissues (NATs) adjacent to tumors and 5 noncancerous gastric mucosa tissue samples. These profiles allowed us to explore the transcriptional characteristics of GC and determine the change patterns in gene expression that may be of clinical significance. 1519 and 1255 differentially-expressed genes (DEGs) were identified in intestinal GC tissues and NATs, respectively, as determined by Bayesian analysis (P < 0.001). These genes were associated with diverse functions such as mucosa secretion, metabolism, proliferation, signaling and development, which occur at different stages of GC development.

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“…22,59 In a study of 42 patients with Helicobacter-associated gastritis, intercellular fluorescein leakage was a predominant functional feature. 60 Eradication of H. pylori reduced this increased leakage to the same levels as healthy controls. However, if morphological consequences such as intestinal metaplasia were not reversed, impaired mucosal barrier function and leakiness persisted despite su ccessful eradication therapy.…”

Section: Translational Science: Functional Imagingmentioning

confidence: 88%

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

Goetz

Malek

Kießlich

2013

Nat Rev Gastroenterol Hepatol

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Performing real-time microscopy has been a vision of endoscopists since the very early phases of gastrointestinal endoscopy. Confocal endomicroscopy, an adaption of confocal laser scanning microscopy, and endocytoscopy, an adaption of white-light microscopy, have been introduced into the endoscopic armamentarium in the past decade. Both techniques yield on-site histological information. Multiple trials have demonstrated the ability of gastroenterologists to obtain and interpret microscopic images from the upper and lower gastrointestinal tract, and also the hepatobiliary-pancreatic system, during endoscopy. Such microscopic information has been successfully used in expert hands to minimize sampling error by 'smart', microscopically targeted biopsies and to guide endoscopic interventions. However, endomicroscopy is also unique in its ability to dynamically visualize cellular processes in their native environment free of artefacts. This ability enables fundamental insights into mechanisms of human diseases in clinical and translational science.

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Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy

Cited by 27 publications

References 40 publications

Correlation of lanthanum dosage with lanthanum deposition in the gastroduodenal mucosa of dialysis patients

Correlation of lanthanum dosage with lanthanum deposition in the gastroduodenal mucosa of dialysis patients

Identification of Differentially-Expressed Genes in Intestinal Gastric Cancer by Microarray Analysis

Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy

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