The therapeutic effect of mitochondria-targeted antioxidant 10-(6´-plastoquinonyl)decyltriphenylphosphonium bromide (SkQ1) in experimental models of acute inflammation and wound repair has been shown earlier. It was suggested that the antiinflammatory activity of SkQ1 is related to its ability to suppress inflammatory activation of the vascular endothelium and neutrophil migration into tissues. Here, we demonstrated that SkQ1 inhibits activation of mast cells (MCs) followed by their degranulation and histamine release in vivo and in vitro. Intraperitoneal injections of SkQ1 in the mouse air-pouch model reduced the number of leukocytes in the air-pouch cavity and significantly decreased the histamine content in it, as well as suppressing MC degranulation in the air-pouch tissue. The direct effect of SkQ1 on MCs was studied in vitro in the rat basophilic leukemia RBL-2H3 cell line. SkQ1 inhibited induced degranulation of RBL-2H3 cells. These results suggest that mitochondrial reactive oxygen species are involved in the activation of MCs. It is known that MCs play a crucial role in regulation of vascular permeability by secreting histamine. Suppression of MC degranulation by SkQ1 might be a significant factor in the antiinflammatory activity of this mitochondria-targeted antioxidant.
The article deals with the problem of mythopoetics in the Yakut literature, in particular, in the works of the first Yakut classical writers A.E. Kulakovsky, A.I. Sofronov, P.A. Oyunsky. Early mythology becomes a sign of one of the sources for the emerging Yakut literature and its national identity, reflecting the original mythological consciousness of the people. Mythological traditions pass into the category of written literature, as they realize its artistic functions. The first writers revealed the ideas of their works through mythopoetics, used mythopoetics in creating unique images and plots. In difficult times for the Yakut people, writers had to create allegorical works in which mythopoetics became a way of allegorical expression of the content of works. Thus, mythopoetics played a huge role in the work of the first Yakut writers. They, using mythopoetics, were able to create their major philosophical works, significant in the Yakut literature to the present day. Writers raised the problems of the survival of the people in the tragic circumstances, deepening and broadening the universal sound of their works.
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