A push-pull dialysis perfusion system for monitoring neurotránsmitter release In deep structures of the brain of freely moving animals Is characterized. The Internal volume of the system has been reduced so that very slow perfusion rates can be used. These slow rates yield high recoveries and small sample volumes, allowing microbore columns with their Inherent Increase In mass sensitivity to be Incorporated into the chromatographic system. Recovery of sample exceeded 90% at 0.1 qL/mln at 37 °C. The maximum sample recovery per minute occurred at approximately 2 gL/mln. The contribution of the perfusion system to sample dispersion was found to be Independent of perfusion rate above 0.1 gL/mln. The detection limit for the neurotransmitter dopamine was 300 fg with a S/N of 2. The method Is suitable for sampling low-molecular-weight molecules In most brain structures.Chemical analysis inside the living brain has long been a difficult problem. Obtaining chemical information with

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A selected group of 195 oils from the Spanish "Toxic Oil" Syndrome (TOS) epidemic including 29 high-probability "case" and 64 "control" oils were examined to investigate the relationship between oil composition and the risk of TOS. As indicated by fatty acid and sterol patterns, the presence of rapeseed oil was significantly more prevalent in the case than in the control oils, but fatty acid anilides were the most useful markers of case-related samples. Anilides were detected in 62% of case oils and at lower concentrations in 23% of the control samples. The ratios of individual anilides were quite constant in these oils and most consistent with their formation in the original (undiluted) rapeseed oil.

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