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A push-pull dialysis perfusion system for monitoring neurotránsmitter release In deep structures of the brain of freely moving animals Is characterized. The Internal volume of the system has been reduced so that very slow perfusion rates can be used. These slow rates yield high recoveries and small sample volumes, allowing microbore columns with their Inherent Increase In mass sensitivity to be Incorporated into the chromatographic system. Recovery of sample exceeded 90% at 0.1 qL/mln at 37 °C. The maximum sample recovery per minute occurred at approximately 2 gL/mln. The contribution of the perfusion system to sample dispersion was found to be Independent of perfusion rate above 0.1 gL/mln. The detection limit for the neurotransmitter dopamine was 300 fg with a S/N of 2. The method Is suitable for sampling low-molecular-weight molecules In most brain structures.Chemical analysis inside the living brain has long been a difficult problem. Obtaining chemical information with

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Myotonic dystrophy (DM) almost always results from the expansion of an unstable (CTG)n repeat. The mutation can be detected directly. Affected patients with cat-