Neuroleptics increase striatal catecholamine metabolites but not ascorbic acid in dialyzed perfusate

Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia

“…Although exact mechanism is not known, direct effect of drugs on lipid peroxidation or indirect effect through alteration in superoxide and hydroxy radical formation could not be ruled out. Atypical antipsychotic like clozapine seems to increase 5-hydroxyindol acetic acid (5-HIAA), which is excellent scavenger of hydroxyl and superoxide radicals (Blakely et al 1984;Liu and Mori 1993). 5-HIAA is also known to inhibit ascorbate-induced lipid peroxidation in rat brain homogenate (Sen and Hanninen 1994).…”

Oxidative Damage and Schizophrenia: The Potential Benefit by Atypical Antipsychotics

“…However, several mechanisms may be proposed to explain the above fi ndings: (i) Clozapine, risperidone, quetiapine and olanzapine up-regulate SOD gene expression and down-regulate p-75 neurotropin receptor mRNA levels in PC12 culture cells, which indicates their neuroprotective potential and prevention of further free radical production in schizophrenic patients [36,37] . (ii) Atypical antipsychotics like clozapine seem to increase 5-hydroxyindoleacetic acid (5-HIAA), which is an excellent scavenger of hydroxyl and superoxide radicals [38,39] . (iii) 5-HIAA inhibits ascorbateinduced lipid peroxidation of rat brain homogenate [35] .…”

Microdialysis in the study of extracellular levels of amino acids in the rat brain

“…All these techniques require sensitive assays, and not until recently has it been possible to analyse the endogenous levels of different compounds routinely. Various Imperato & Di Chiara (1984), Blakely et al (1984), Johnson & Justice (1983), and Clemens & Phebus (1984) have used it to study the dopamine systen in vivo, and finally Brodin et al (1983) and Lindefors et al (1985) have studied brain peptides with it. This paper gives an account ofthe microdialysis method used by us to study amino acid mechanisms in the brain.…”