Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia

Dakhale, Ganesh N.; Khanzode, Suchet D.; Khanzode, Shruti; Saoji, Anand

doi:10.1007/s00213-005-0117-1

Cited by 115 publications

(78 citation statements)

References 23 publications

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“…Arvindakshan et al (2003) demonstrated that there was a significant reduction in the clinical signs of SZ and an increase in the quality of life of schizophrenic patients that were supplemented with AA combined with D-tocopherol and omega 3 twice a day for a period of 4 months. Another study conducted by Dakhale et al (2005) evaluated the effects of AA supplementation in schizophrenic patients treated with atypical antipsychotics for a period of eight weeks, and found that there was a reduction in the levels of oxidative damage, as well as an improvement in the scores on the Brief Psychiatric Rating Scale of SZ. A recent study has also shown that supplementation with AA (5 mg/l) decreased the effects of neurotoxicity induced by aluminum by reducing the damage within neurotransmitters (serotonin, norepinephrine, dopamine), so decreasing the levels of apoptosis and restoring the morphology of the brain tissue in Nile catfish (Khalili and Hussein 2015).…”

Section: Discussionmentioning

confidence: 99%

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

Damázio

Silveira

Canever

et al. 2017

An. Acad. Bras. Ciênc.

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Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the hyperlocomotion induced by ket. Ket also showed an increase of AChE activity within the prefrontal cortex and striatum prevented by AA. Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder.

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Section: Discussionmentioning

confidence: 99%

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

Damázio

Silveira

Canever

et al. 2017

An. Acad. Bras. Ciênc.

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“…Studies developed by Zhang et al(2001a; indicated that ginkgo biloba adds haloperidol attribute to chronic or resistant schizophrenia. And supplementation of vitamin C with atypical antipsychotics can reduce oxidative stress and improve the outcome of schizophrenia (Dakhale et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Chen

et al. 2006

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV) criteria for schizophrenia and fifty age-and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.

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“…Serum Thiobarbituric Acid Reacting Substances (TBARS) was selected as marker of oxidative stress induced lipid peroxidation. As ascorbate was found to play the role of chief antioxidant in the brain in several studies (13), plasma ascorbate was selected as the indicator for antioxidant activity. Thirty properly matched healthy persons meeting the inclusion/ exclusion criteria were also assessed for serum TBARS and plasma ascorbate.…”

Section: Methodsmentioning

confidence: 99%

Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

Chakraborty

Dasgupta

Das

et al. 2009

Indian J Clin Biochem

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Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia

Abstract: Oral supplementation of vitamin C with atypical antipsychotic reverses ascorbic acid levels, reduces oxidative stress, and improves BPRS score, hence both the drugs in combination can be used in the treatment of schizophrenia.

Cited by 115 publications

References 23 publications

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

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