Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

Chakraborty, Sutirtha; Dasgupta, Anindya; Das, Harendra Nath; Singh, Om Prakash; Mandal, Asok Kumar; Mandal, Nikhiles

doi:10.1007/s12291-009-0035-9

Cited by 23 publications

(24 citation statements)

References 15 publications

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“…One such mechanism may involve oxidative stress, evidence of which has been described in OCD (Behl et al, 2010; Chakraborty et al, 2009; Selek et al, 2008). OCD is associated with polymorphisms of the neuronal glutamate transporter (EAAC1) gene, which mediates cysteine uptake necessary for neuronal glutathione (GSH) production (Aoyama et al, 2006; Monteiro and Feng, 2016).…”

Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

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Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests.

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Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning

confidence: 99%

Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

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“…[115][116][117][118][119] Some investigators have also found markers of oxidative stress in the brain tissues of patients with OCD. [120][121][122] Moreover, Kuloglu et al 120 showed significantly lower levels of vitamin E and C, and higher levels of malondialdehyde (MDA) in patients with OCD compared to controls, suggesting that OCD is linked to oxidative stress. Free radicals in the brain are mainly produced by catecholamine metabolism, and this increase in catecholaminergic metabolism seems to be associated with increased tissue damage.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

Streck

Gonçalves

Furlanetto

et al. 2014

Rev. Bras. Psiquiatr.

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Introduction: Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders. Methodology: We reviewed articles that evaluated mitochondrial dysfunction and psychiatric disorders, with a particular focus on depression, bipolar disorder, anxiety disorders, obsessivecompulsive disorder, and autism spectrum disorder, and the association between mitochondrial dysfunction and development of these disorders. Results: Evidence suggests that alterations in mitochondrial morphology, brain energy metabolism, and mitochondrial enzyme activity may be involved in the pathophysiology of different neuropsychiatric disorders, given their key role in energy metabolism in the cell. Conclusions: Understanding the interactions between mitochondrial dysfunction and development of psychiatric disorders may help establish more effective therapeutic strategies for these disorders and thus lead to better outcomes for affected subjects.

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“…MDA is ubiquitous compound produced in substantial quantity in mammalian tissues both as an end product of unsaturated lipid peroxidation and as a side product of prostaglandin and thromboxane biosynthesis. it is also produced by γ-irradiation of carbohydrates [9,10].…”

Section: Malondialdehyde (Mda)mentioning

confidence: 99%

“…It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine [11][12][13][14] (Figure 6). …”

Section: Under Physiological Conditions Ph 74mentioning

confidence: 99%

Role of Oxidative Stress in the Pathogenesis of OCD

Tk¹

2015

Biochem Anal Biochem

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Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

Abstract: ABSTRACT

Cited by 23 publications

References 15 publications

Obsessive-compulsive disorder: Insights from animal models

Obsessive-compulsive disorder: Insights from animal models

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

Role of Oxidative Stress in the Pathogenesis of OCD

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