2014
DOI: 10.1590/1516-4446-2013-1224
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Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

Abstract: Introduction: Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders. Methodology: We reviewed articles that evaluated mitochondrial dysfunction and psychiatric disorders, with a particular focus on depression, bipolar disorder, anxiety disor… Show more

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Cited by 74 publications
(53 citation statements)
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“…challenges (32) and contribute to the development of psychopathologies (9,10,13,14). Therefore, our results highlight differences in mitochondrial function in the NAc as a potential mechanism underlying the susceptibility or resilience to develop depression, and may open new prospects for the advancement of preventive therapeutic approaches to mood disorders.…”
Section: Discussionmentioning
confidence: 66%
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“…challenges (32) and contribute to the development of psychopathologies (9,10,13,14). Therefore, our results highlight differences in mitochondrial function in the NAc as a potential mechanism underlying the susceptibility or resilience to develop depression, and may open new prospects for the advancement of preventive therapeutic approaches to mood disorders.…”
Section: Discussionmentioning
confidence: 66%
“…Recent work has highlighted the potential for individual differences in mitochondrial function and, more broadly, energy metabolism to influence vulnerability to develop psychopathological disorders, such as anxiety and depression (9)(10)(11)(12)(13)(14). Here, we demonstrate that trait anxiety is a determining factor of social rank that is mediated by brain regionspecific mitochondrial function.…”
mentioning
confidence: 53%
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“…Por un lado, se descartan a los seres humanos con características genéticas no deseadas y, por otro, se mejoran las características genéticas de las personas, perdiendo su identidad. Si bien se modifica un porcentaje pequeño de la información genética, existe una importante conexión entre el ADN nuclear y el ADN mitocondrial que no solo se interviene en la función bioenérgetica de las mitocondrias en el funcionamiento celular, sino que se describe más frecuentemente la contribución mitocondrial a la capacidad de neuroplasticidad y al desarrollo de la personalidad (43,44).…”
Section: Gestación Deliberada De Embriones Humanos Como Materials Biteunclassified
“…Recently, it has been proposed that apart from a deficiency of monoamine transmission, neuroendocrine changes and a dysregulation of the immune system, depression, bipolar disorder and anxiety disorders may be associated with mitochondrial dysfunction (Gardner and Boles, 2011;Streck et al, 2014;Tobe, 2013). It is widely recognized that mitochondria play a pivotal role in cellular energy metabolism by generation of ATP -a source of chemical energy.…”
Section: Introductionmentioning
confidence: 99%