Background and Objective:This study aimed to investigate the systemic effect of dietary supplement omega 3 (ω-3) polyunsaturated fatty acids (PUFAs ) and propolis as an adjunct to non surgical periodontal therapy and evaluate the gingival crevicular fluid level of receptor activator of nuclear factor κ ligand (RANKL). Material and Methods:Forty-five subjects with stage II or III and grade B periodontitis were included in this study. They were randomly assigned into three groups: Group I: 15 subjects received scaling and root planing (SRP) only. Group II: 15 subjects received SRP combined with daily dietary supplementation of omega 3 for 6 months. Group III: 15 subjects received SRP combined with a daily dietary supplement of propolis for 6 months. Clinical parameter (plaque index, bleeding index, pocket depth, and clinical attachment level) and biochemical analysis of RANKL in GCF were recorded at baseline, 3 months and 6 months after treatments Results: Statistical analysis revealed that both (ω-3) and propolis statistically significant (P≤0.01) reduce PD and CAL at 3 and 6 months compared to its baseline and control group. RANKL level in GCF statistically significant (P≤0.01) reduced at 3 and 6 months in both treated groups compared to its baseline and control group. No statistical significant (P≥0.05) difference between both treated groups concerning clinical and biochemical parameters.Conclusion: The present study suggests that dietary supplementation with ω-3 PUFAs or propolis effective as an adjunct to nonsurgical periodontal therapy in the management of patients with periodontitis.

Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stability for the cells in produced tissues, and replicate the native tissues, hydrogels have been utilized as one of the most frequent tissue engineering scaffolds during the last twenty years. Hydrogels’ high water content can provide an excellent conditions for cell viability as well as an architecture that mimics real tissues, bone, and cartilage. Hydrogels have been used to enable cell immobilization and growth factor application. This paper summarizes the features, structure, synthesis and production methods, uses, new challenges, and future prospects of bioactive polymeric hydrogels in dental and osseous tissue engineering of clinical, exploring, systematical and scientific applications.

For several years, ceramic biomaterials have been extensively utilized to rebuild and substitute for body tissues. Calcium silicates have been proven to exhibit excellent bioactivity due to apatite formation and cell proliferation stimulation, in addition to degradability at levels adequate for hard tissue formation. These ceramics' excellent biological characteristics have attracted researchers. Baghdadite is a calcium silicate incorporating zirconium ions that enhances human osteoblast multiplication and development, increasing mineralization, and ossification. It has currently received much interest in academic institutions and has been extensively explored in the form of permeable frameworks, varnishes, bone adhesive and gap fillings, microparticles, and nanospheres, particularly in a wide range of biomedical applications. This review article aims to summarize and analyze the most recent research on baghdadite's mechanical characteristics, apatite-forming capability, dissolution pattern, and physiochemical qualities as a scaffold for dentofacial tissuèregeneration purposes.

Background and Objective: Periostin is a protein highly expressed within extracellular matrix of bone and periodontal ligament responsible for tissue integrity and play significant role in wound repair and bone remodeling. The present study designed to estimate the effectiveness of non surgical periodontal therapy (NSPT) on level of periostin in the gingival crevicular fluid (GCF) of diabetic patient with periodontitis. Materials and Methods: 36 subjects were admitted in this study. The subjects allocated into 3 groups, Group I involve 12 periodontally healthy subjects, Group II involve 12 participants with periodontitis. Group III: involve 12 participants with periodontitis diagnosed with diabetes mellites type II. Group II and III were received conventional periodontal treatment scaling and root planning (S&RP). Clinical parameters: pocket depth (PD), clinical attachment loss (CAL), gingival index (GI), plaque index (PI) were measured and the GCF samples were gathered for assessment of periostin at baseline and at 3 months postoperatively. Results: Periostin level in the GCF were significantly increased in healthy subjects (P≤0.001) compared to those with diabetic patients with periodontitis and patients with periodontitis only. NSPT in group II and III resulted in significant increase (P≤0.001) in periostin level at 3 months postoperatively. Conclusion: NSPT can significantly increase the level of periostin in the GCF of diabetic patients with periodontitis and those with periodontitis only. Moreover, periostin suggested to be inflammatory marker reliable for diagnosis and evaluation of the outcome of periodontal treatment.

Background:In individuals who have an excessive gingival display, gingival hyperpigmentation is an aesthetic issue. The goal of this study was to examine the effectiveness of the minimally invasive microneedling (MN) approach in the treatment of gingival hyperpigmentation. Patients and methods:A total of 40 people with gingival hyperpigmentation were split into two groups at random. Group I: was managed with the surgical scalpel method, whereas group II was managed with MN approach. At the time of the procedures, the bleeding was compared. On the first and seventh days after the depigmentation procedures, wound healing and pain severity were assessed while at 1 month and 6 months following the treatments, the oral pigmentation indices were assessed. Results:When compared to baseline data, both groups demonstrated a substantial reduction in oral pigmentation indices at 1 and 6 months, while group I demonstrated a statistically significant (P≤0.05) improvement compared to group II. There was a significant decrease (P≤0.001) in the bleeding index and pain severity and improvement in wound healing in MN treated group compared to the surgically-treated group. Conclusion:MN successfully reduces gingival hyperpigmentation and might be regarded as an alternative minimally invasive treatment option.

Background: the aim of this study was to evaluate and compare the effectiveness of root coverage with coronally advanced flap combined with Platelet Rich Fibrin or Fresh Amniotic Membrane. Materials and Methods: thirty patients had Miller class I or II in maxillary anterior teeth were involved in the present study. Each recession defect was randomly assigned to one of the treating groups: coronally advanced flap with Platelet rich fibrin (PRF group) and coronally advanced flap with fresh amniotic membrane (AM) (AM Group). Clinical measurements of recession depth (RD), root coverage percentage (RC%) pocket depth (PD), clinical attachment level (CAL) and width of keratinized tissue (WKT) were evaluated at the baseline, three months, six months and nine months postoperatively. Statistical analysis was performed for intergroup and intragroup comparisons respectively. Results: intragroup comparison displayed statistical significant difference with regard to RD and CAL at different time interval. No statistical significant difference between groups at different time interval with regard to RD, PD, CAL while WKT, AM group demonstrated statistical significant increase compared to PRF group. Conclusion: Both the membranes provided successful and predictable root coverage when combined with CAF. AM was more effective in terms of increase in WKT.

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