Aim The present study aimed to monitor the clinical outcomes and the metabolic response of periodontal therapy (non‐surgical) in patients with periodontitis (chronic) and uncontrolled diabetes (type 2). Methods Eighty‐eight subjects with periodontitis (chronic) and uncontrolled diabetes (type 2) were enrolled in this controlled trial and allocated randomly to the test group (44 patients were received immediate periodontal therapy) or the control group (44 patients were received delayed periodontal therapy). The metabolic and clinical evaluations were conducted at baseline and 3 months. This included clinical attachment level, glycated hemoglobin (HbA1c), bleeding on probing, visible plaque, and pocket depth. The periodontal therapy in this study consists of one‐stage scaling and root planning, a combination of systemic antibiotics (amoxicillin 500 mg and metronidazole 400 mg), and oral hygiene instructions. Results Regarding clinical and metabolic parameters at baseline, no statistically significant differences were displayed between the two groups. However, at 3‐month follow‐up period the patients within the test group demonstrated significantly better clinical and metabolic outcomes than patients in the control group. Conclusion The non‐surgical periodontal treatment using a combination of metronidazole and amoxicillin significantly improved the metabolic outcome in addition to periodontal health in diabetic subjects with chronic periodontitis.

Background and Objective:This study aimed to investigate the systemic effect of dietary supplement omega 3 (ω-3) polyunsaturated fatty acids (PUFAs ) and propolis as an adjunct to non surgical periodontal therapy and evaluate the gingival crevicular fluid level of receptor activator of nuclear factor κ ligand (RANKL). Material and Methods:Forty-five subjects with stage II or III and grade B periodontitis were included in this study. They were randomly assigned into three groups: Group I: 15 subjects received scaling and root planing (SRP) only. Group II: 15 subjects received SRP combined with daily dietary supplementation of omega 3 for 6 months. Group III: 15 subjects received SRP combined with a daily dietary supplement of propolis for 6 months. Clinical parameter (plaque index, bleeding index, pocket depth, and clinical attachment level) and biochemical analysis of RANKL in GCF were recorded at baseline, 3 months and 6 months after treatments Results: Statistical analysis revealed that both (ω-3) and propolis statistically significant (P≤0.01) reduce PD and CAL at 3 and 6 months compared to its baseline and control group. RANKL level in GCF statistically significant (P≤0.01) reduced at 3 and 6 months in both treated groups compared to its baseline and control group. No statistical significant (P≥0.05) difference between both treated groups concerning clinical and biochemical parameters.Conclusion: The present study suggests that dietary supplementation with ω-3 PUFAs or propolis effective as an adjunct to nonsurgical periodontal therapy in the management of patients with periodontitis.

Chitosan is a natural anionic polysaccharide with a changeable architecture and an abundance of functional groups; in addition, it can be converted into various shapes and sizes, making it appropriate for a variety of applications. This article examined and summarized current developments in chitosan-based materials, with a focus on the modification of chitosan, and presented an abundance of information about the fabrication and use of chitosan-derived products in periodontal regeneration. Numerous preparation and modification techniques for enhancing chitosan performance, as well as the uses of chitosan and its metabolites, were reviewed critically and discussed in depth in this study. Chitosan-based products may be formed into different shapes and sizes, considering fibers, nanostructures, gels, membranes, and hydrogels. Various drug-loaded chitosan devices were discussed regarding periodontal regeneration.

Background: the aim of this study was to evaluate and compare the effectiveness of root coverage with coronally advanced flap combined with Platelet Rich Fibrin or Fresh Amniotic Membrane. Materials and Methods: thirty patients had Miller class I or II in maxillary anterior teeth were involved in the present study. Each recession defect was randomly assigned to one of the treating groups: coronally advanced flap with Platelet rich fibrin (PRF group) and coronally advanced flap with fresh amniotic membrane (AM) (AM Group). Clinical measurements of recession depth (RD), root coverage percentage (RC%) pocket depth (PD), clinical attachment level (CAL) and width of keratinized tissue (WKT) were evaluated at the baseline, three months, six months and nine months postoperatively. Statistical analysis was performed for intergroup and intragroup comparisons respectively. Results: intragroup comparison displayed statistical significant difference with regard to RD and CAL at different time interval. No statistical significant difference between groups at different time interval with regard to RD, PD, CAL while WKT, AM group demonstrated statistical significant increase compared to PRF group. Conclusion: Both the membranes provided successful and predictable root coverage when combined with CAF. AM was more effective in terms of increase in WKT.

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For several years, ceramic biomaterials have been extensively utilized to rebuild and substitute for body tissues. Calcium silicates have been proven to exhibit excellent bioactivity due to apatite formation and cell proliferation stimulation, in addition to degradability at levels adequate for hard tissue formation. These ceramics' excellent biological characteristics have attracted researchers. Baghdadite is a calcium silicate incorporating zirconium ions that enhances human osteoblast multiplication and development, increasing mineralization, and ossification. It has currently received much interest in academic institutions and has been extensively explored in the form of permeable frameworks, varnishes, bone adhesive and gap fillings, microparticles, and nanospheres, particularly in a wide range of biomedical applications. This review article aims to summarize and analyze the most recent research on baghdadite's mechanical characteristics, apatite-forming capability, dissolution pattern, and physiochemical qualities as a scaffold for dentofacial tissuèregeneration purposes.