Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Abstract

Chitosan is a natural anionic polysaccharide with a changeable architecture and an abundance of functional groups; in addition, it can be converted into various shapes and sizes, making it appropriate for a variety of applications. This article examined and summarized current developments in chitosan-based materials, with a focus on the modification of chitosan, and presented an abundance of information about the fabrication and use of chitosan-derived products in periodontal regeneration. Numerous preparation and modification techniques for enhancing chitosan performance, as well as the uses of chitosan and its metabolites, were reviewed critically and discussed in depth in this study. Chitosan-based products may be formed into different shapes and sizes, considering fibers, nanostructures, gels, membranes, and hydrogels. Various drug-loaded chitosan devices were discussed regarding periodontal regeneration.

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

“…Periodontitis is an inflammation produced by the deposition of pathogens that cause gradual damage to the supporting tissues of dentition . To facilitate periodontal regeneration, local medication delivery for the periodontal cavity is in urgent need.…”

“…Periodontitis is an inflammation produced by the deposition of pathogens that cause gradual damage to the supporting tissues of dentition. 170 To facilitate periodontal regeneration, local medication delivery for the periodontal cavity is in urgent need. Therefore, Santos et al synthesized core−sheath nanostructured chitosan-based nonwovens as a drug carrier for treating periodontitis.…”

Chitosan-Based Biomaterials for Tissue Regeneration

“…Furthermore, chitosan can be fabricated into a variety of formulations such as nanoparticles, nanofibers, scaffolds, hydrogels, membranes, films, and many others which makes it suitable for particular biomedical applications [ 5 ]. A variety of techniques are utilized to prepare different chitosan formulations such as ionic gelation, solvent evaporation, reverse micellar, cross-linking, self-assembling, sieving, spray drying, and freeze-drying [ 6 ]. For instance, ionic gelation and sieving methods are used to produce chitosan nanoparticles while physical and chemical cross-linking are deployed to synthesize hydrogels [ 7 ].…”

Baghdadite: A Novel and Promising Calcium Silicate in Regenerative Dentistry and Medicine

“…Scaffold-based treatments, which use a porous material, provide an alternate method for stimulating bone development in bone lesions. − Considerable attempts have been made to create a superb artificial scaffolding, which mimics structural properties of bone while also providing the required porosity, interconnectivity, biocompatibility, and mechanical properties. − Given the popularity of these operations, there is no perfect bone transplant alternative . The need for biosynthetic substances for the restoration and healing of bone tissue loss caused by injury or illness has expanded dramatically in the last 10 years …”